Enantioselective Alkylation of Amino Acid Derivatives with Unactivated Olefins via C-N Bond Cleavage

被引：0
作者：
Cai, Yue-Ming [1 ]
Shang, Ming [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Frontiers Sci Ctr Transformat Mol, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China
来源：
SYNLETT | 2023年 / 34卷 / 08期
基金：
中国国家自然科学基金;
关键词：
deaminative alkylation; enantioselective; chiral bis(oxazoline) ligands; alpha-amino acid; sp(3) cross-coupling; NICKEL-CATALYZED BORYLATION; BENZYLIC AMMONIUM-SALTS; CROSS-COUPLINGS; H FUNCTIONALIZATION; REDUCTIVE ARYLATION; NATURAL-PRODUCTS; BORONIC ACIDS; REMOTE; LIGANDS; ARYL;
D O I：
10.1055/s-0042-1752337
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We reported a nickel-catalyzed enantioconvergent deaminative alkylation of a-amino acid derivatives with unactivated olefins, providing an efficient and convenient access to a range of a-enantioenriched amides. This method represents the first example of enantioselective deaminative functionalization with racemic amine precursors and features in mild conditions and broad substrate scope. New sterically encumbered bis(oxazoline) ligand was developed to improve both reactivity and enantioselectivity, which is key to the success of this reaction.
引用
收藏
页码：875 / 881
页数：7
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