Preliminary study of the safety of acrinol in probe-based confocal laser endomicroscopy during transurethral resection of bladder tumors

被引：0

作者：

Naya, Yoshio ^{[1
,2
,3
]}

Takaha, Natsuki ^{[1
]}

Hayashi, Iseei ^{[2
]}

Mori, Masaru ^{[2
]}

Date, Seiki ^{[2
]}

Ukimura, Osamu ^{[3
]}

机构：

[1] Meiji Univ Integrat Med, Dept Urol, Nantan, Japan

[2] Nagahama City Kohoku Hosp, Dept Urol, 1221 Kuroda,Kinomoto Cho, Nagahama, Shiga 5290493, Japan

[3] Kyoto Prefectural Univ Med, Dept Urol, Kyoto, Japan

来源：

ASIAN JOURNAL OF ENDOSCOPIC SURGERY | 2023年 / 16卷 / 01期

关键词：

acrinol; laser optical fiber; urinary bladder neoplasms; CYSTOSCOPY;

D O I：

10.1111/ases.13103

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

We previously reported that probe-based confocal laser endomicroscopy using acrinol can depict cancerous nuclei. The objective of this study was to confirm the safety of acrinol in patients. For all seven patients, '50 ml' of a 0.1% acrinol and '1 ml' of 10% fluorescein in 99 ml of normal saline were introduced into the bladder. The laser probe adhered to the suspicious lesion from the working channel of the cystoscope. The patients underwent mucosal biopsy and transurethral resection after observation. Adverse events were noted during a valuation using common terminology criteria for adverse events version 4.0. Confocal laser endomicroscopy detected the nuclei of cancer cells in all seven patients. No adverse event was observed in any of the seven patients. Confocal laser endomicroscopy using acrinol as a novel dye can help visualize the cancerous nuclei of bladder urothelial carcinoma during cystoscopy without severe adverse events.

引用

页码：143 / 146

页数：4

共 10 条

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