Combating Antimicrobial Resistance by Employing Antimicrobial Peptides: Immunomodulators and Therapeutic Agents against Infectious Diseases

被引:10
作者
Mehraj, Insha [1 ]
Hamid, Aflaq [2 ]
Gani, Ubaid [1 ]
Iralu, Nulevino [2 ]
Manzoor, Tasaduq [1 ]
Bhat, Sahar Saleem [1 ]
机构
[1] Sher e Kashmir Univ Agr Sci & Technol Kashmir, Fac Vet Sci & Anim Husb, Div Anim Biotechnol, Srinagar 05466, Jammu & Kashmir, India
[2] Sher e Kashmir Univ Agr Sci & Technol Kashmir, Srinagar 05466, Jammu & Kashmir, India
关键词
antimicrobial peptides; antimicrobial resistance; antibacterial; antiviral; antifungal; antibiofilm; delivery systems; immunomodulatory; HOST-DEFENSE PEPTIDES; ANTIBIOTIC-RESISTANCE; MECHANISMS; BIOFILMS; BACTERIA;
D O I
10.1021/acsabm.3c01104
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
The rising prevalence of multiple-drug-resistant pathogens poses a formidable challenge to conventional antimicrobial treatments. The inability of potent antibiotics to combat these "superbugs" underscores the pressing need for alternative therapeutic agents. Antimicrobial peptides (AMPs) represent an alternative class of antibiotics. AMPs are essential immunomodulatory molecules that are found in various organisms. They play a pivotal role in managing microbial ecosystems and bolstering innate immunity by targeting and eliminating invading microorganisms. AMPs also have applications in the agriculture sector by combating animal as well as plant pathogens. AMPs can be exploited for the targeted therapy of various diseases and can also be used in drug-delivery systems. They can be used in synergy with current treatments like antibiotics and can potentially lead to a lower required dosage. AMPs also have huge potential in wound healing and regenerative medicine. Developing AMP-based strategies with improved safety, specificity, and efficacy is crucial in the battle against alarming global microbial resistance. This review will explore AMPs' increasing applicability, their mode of antimicrobial activity, and various delivery systems enhancing their stability and efficacy.
引用
收藏
页码:2023 / 2035
页数:13
相关论文
共 79 条
  • [1] Echinocandins: The Expanding Antifungal Armamentarium
    Aguilar-Zapata, Daniel
    Petraitiene, Ruta
    Petraitis, Vidmantas
    [J]. CLINICAL INFECTIOUS DISEASES, 2015, 61 : S604 - S611
  • [2] Interactions of an Anionic Antimicrobial Peptide with Zinc(II): Application to Bacterial Mimetic Membranes
    Almarwani, Bashiyar
    Phambu, Nsoki
    Hamada, Yahia Z.
    Sunda-Meya, Anderson
    [J]. LANGMUIR, 2020, 36 (48) : 14554 - 14562
  • [3] Antibiofilm Peptides and Peptidomimetics with Focus on Surface Immobilization
    Andrea, Athina
    Molchanova, Natalia
    Jenssen, Havard
    [J]. BIOMOLECULES, 2018, 8 (02)
  • [4] The Potential Use of Natural and Structural Analogues of Antimicrobial Peptides in the Fight against Neglected Tropical Diseases
    Angelique, Lewies
    Frederik, Wentzel Johannes
    Garmi, Jacobs
    Hester, Du Plessis Lissinda
    [J]. MOLECULES, 2015, 20 (08) : 15392 - 15433
  • [5] Anunthawan T., 2015, CATIONICAMPHIPATHIC
  • [6] Antimicrobial Peptides
    Bahar, Ali Adem
    Ren, Dacheng
    [J]. PHARMACEUTICALS, 2013, 6 (12) : 1543 - 1575
  • [7] Antimicrobial peptides and their interaction with biofilms of medically relevant bacteria
    Batoni, Giovanna
    Maisetta, Giuseppantonio
    Esin, Semih
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2016, 1858 (05): : 1044 - 1060
  • [8] Antimicrobial peptides: Pore formers or metabolic inhibitors in bacteria?
    Brogden, KA
    [J]. NATURE REVIEWS MICROBIOLOGY, 2005, 3 (03) : 238 - 250
  • [9] Bovine lactoferrin activity against Chikungunya and Zika viruses
    Carvalho, Carlos A. M.
    Casseb, Samir M. M.
    Goncalves, Rafael B.
    Silva, Eliana V. P.
    Gomes, Andre M. O.
    Vasconcelos, Pedro F. C.
    [J]. JOURNAL OF GENERAL VIROLOGY, 2017, 98 (07) : 1749 - 1754
  • [10] Relationship Between Biofilm Formation and Antimicrobial Resistance in Gram-Negative Bacteria
    Cepas, Virginio
    Lopez, Yuly
    Munoz, Estela
    Rolo, Dora
    Ardanuy, Carmen
    Marti, Sara
    Xercavins, Mariona
    Pablo Horcajada, Juan
    Bosch, Jordi
    Soto, Sara M.
    [J]. MICROBIAL DRUG RESISTANCE, 2019, 25 (01) : 72 - 79