Ultrasound-Assisted Synthesis of Benzimidazole Derivatives: A Catalyst-Free Green Chemistry Approach

被引：1

作者：

Shah, Drashti ^{[1
]}

Patel, Ashish ^{[1
]}

Patel, Stuti ^{[1
]}

Mehta, Meshwa ^{[1
]}

Patel, Yug ^{[1
]}

Bhimani, Bhargav ^{[2
]}

Bambharoliya, Tushar ^{[3
]}

机构：

[1] Charotar Univ Sci & Technol, Ramanbhai Patel Coll Pharm, CHARUSAT Campus, Changa 388421, India

[2] Piramal Pharma, Pharmaceut Special Econ Zone, Ahmadabad 382213, India

[3] North Carolina State Univ, Raleigh, NC 27695 USA

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 59卷 / 08期

关键词：

Benzimidazole; ultrasound-assisted synthesis; green chemistry; one-pot synthesis; catalyst-free; HIGHLY EFFICIENT SYNTHESIS; SOLVENT-FREE SYNTHESIS; 2-SUBSTITUTED BENZIMIDAZOLES; HETEROGENEOUS CATALYST; BIOLOGICAL EVALUATION; ROOM-TEMPERATURE; 2-ARYLBENZIMIDAZOLES; BENZOTHIAZOLES; INHIBITORS; BINDING;

D O I：

10.1134/S1070428023080146

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A green and effective catalyst-free ultrasound-assisted synthetic methodology for benzimidazole derivatives has been developed. A total of fifteen derivatives have been prepared through sonochemistry, which needed shorter reaction times for completion (8-30 min) and occurred in high yields (92-95%). The synthesized benzimidazole derivatives were identified by comparing their physicochemical and spectral characteristics with the respective published data for the authentic samples.

引用

页码：1397 / 1406

页数：10

共 71 条

[1] Synthesis and Antibacterial Evaluation of Some Novel Imidazole and Benzimidazole Sulfonamides [J].

Al-Mohammed, Nassir N. ;

Alias, Yatimah ;

Abdullah, Zanariah ;

Shakir, Raied M. ;

Taha, Ekhlass M. ;

Hamid, Aidil Abdul .

MOLECULES, 2013, 18 (10) :11978-11995

[2] Synthesis and Evaluation of Selected Benzimidazole Derivatives as Potential Antimicrobial Agents [J].

Alasmary, Fatmah A. S. ;

Snelling, Anna M. ;

Zain, Mohammed E. ;

Alafeefy, Ahmed M. ;

Awaad, Amani S. ;

Karodia, Nazira .

MOLECULES, 2015, 20 (08) :15206-15223

[3]

Andrade CKZ, 2005, CURR ORG CHEM, V9, P195

[4] Highly efficient water-mediated approach to access benzazoles: metal catalyst and base-free synthesis of 2-substituted benzimidazoles, benzoxazoles, and benzothiazoles [J].

Bala, Manju ;

Verma, Praveen Kumar ;

Sharma, Deepika ;

Kumar, Neeraj ;

Singh, Bikram .

MOLECULAR DIVERSITY, 2015, 19 (02) :263-272

[5] Ultrasound and Nano-Catalysts: An Ideal and Sustainable Combination to Carry out Diverse Organic Transformations [J].

Banerjee, Bubun .

CHEMISTRYSELECT, 2019, 4 (08) :2484-2500

[6]

BARKER HA, 1960, J BIOL CHEM, V235, P480

[7] Magnetically separable MnFe2O4 nano-material: an efficient and reusable heterogeneous catalyst for the synthesis of 2-substituted benzimidazoles and the extended synthesis of quinoxalines at room temperature under aerobic conditions [J].

Brahmachari, Goutam ;

Laskar, Sujay ;

Barik, Puspendu .

RSC ADVANCES, 2013, 3 (34) :14245-14253

[8] Synthesis and biological evaluation of benzimidazole-5-carbohydrazide derivatives as antimalarial, cytotoxic and antitubercular agents [J].

Camacho, Jose ;

Barazarte, Arthur ;

Gamboa, Neira ;

Rodrigues, Juan ;

Rojas, Rosario ;

Vaisberg, Abraham ;

Gilman, Robert ;

Charris, Jaime .

BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 19 (06) :2023-2029

[9] A Simple, Mild, and Efficient Procedure for High-Yield Synthesis of Benzimidazoles Using Coppertriflate as Catalyst [J].

Chari, M. Adharvana ;

Sadanandam, P. ;

Shobha, D. ;

Mukkanti, K. .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2010, 47 (01) :153-155

[10] Nanoporous aluminosilicate catalyst with 3D cage-type porous structure as an efficient catalyst for the synthesis of benzimidazole derivatives [J].

Chari, Murugulla A. ;

Shobha, D. ;

Kenawy, El-Refaie ;

Al-Deyab, Salem S. ;

Reddy, B. V. Subba ;

Vinu, Ajayan .

TETRAHEDRON LETTERS, 2010, 51 (39) :5195-5199

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