Case report: Presentations and cytokine profiles of inflammatory non-pulmonary COVID-19 and related diseases in children

被引：0

作者：

Chao, Yen-Chun ^{[1
,2
,3
]}

Yang, Horng-Woei ^{[4
]}

Chang, Lung ^{[2
,3
,4
,5
]}

Tseng, Chih-Wen ^{[4
]}

Fang, Li-Ching ^{[2
,3
,4
,6
]}

Ho, Che-Sheng ^{[2
,3
,7
]}

Chi, Hsin ^{[2
,3
,4
,5
]}

Yang, Kuender D. ^{[2
,4
,6
,8
,9
]}

机构：

[1] MacKay Childrens Hosp, Div Cardiol, Taipei, Taiwan

[2] Mackay Mem Hosp, Dept Pediat, Taipei, Taiwan

[3] Mackay Med Coll, Dept Med, Taipei, Taiwan

[4] Mackay Mem Hosp, Dept Med Res, Taipei, Taiwan

[5] MacKay Childrens Hosp, Div Infect Dis, Taipei, Taiwan

[6] MacKay Childrens Hosp, Div Allergy Immunol Rheumatol, Taipei, Taiwan

[7] MacKay Childrens Hosp, Div Neurol, Taipei, Taiwan

[8] Natl Yang Ming Chiao Tung Univ, Inst Clin Med, Taipei, Taiwan

[9] Natl Def Med Ctr, Dept Microbiol & Immunol, Taipei, Taiwan

来源：

FRONTIERS IN PEDIATRICS | 2023年 / 11卷

关键词：

coronavirus disease 2019; non-pulmonary COVID-19; meningoencephalitis; acute necrotizing encephalopathy; multisystem inflammatory syndrome in children; SARS-CoV-2; VACCINATION;

D O I：

10.3389/fped.2023.1209772

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The coronavirus disease 2019 (COVID-19) pandemic has evolved to dynamic waves of different SARS-CoV-2 variants. Initially, children diagnosed with COVID-19 presented pulmonary involvement characterized by mild diseases. In the later waves of the COVID-19 pandemic, life-threatening non-pulmonary inflammatory diseases such as (1) aseptic meningoencephalitis (ME), (2) acute necrotizing encephalopathies (ANE), and (3) multisystem inflammatory syndrome in children (MIS-C) have been reported, affecting the pediatric population. To alert timely identification and prevention of the life-threatening non-pulmonary COVID-19, we present the cases of ME, ANE, and MIS-C in terms of clinical manifestation, cytokine profile, and follow-up consequences. Based on the immunopathogenesis and risk factors associated with non-pulmonary COVID-19, we delineate strategies for an early diagnosis and treatment to reduce morbidity and mortality in children.

引用

页数：7

共 41 条

[1] Pathogenesis and Preventive Tactics of Immune-Mediated Non-Pulmonary COVID-19 in Children and Beyond
Chi, Hsin
Chang, Lung
Chao, Yen-Chun
Lin, Dar-Shong
Yang, Horng-Woei
Fang, Li-Chih
Lin, Chia-Hsueh
Ho, Che-Sheng
Yang, Kuender D.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (22)
[2] Multisystem Inflammatory Syndrome in Children Related to COVID-19: the First Case in Korea
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JOURNAL OF KOREAN MEDICAL SCIENCE, 2020, 35 (43) : e391
[3] Four cases of cytokine storm after COVID-19 vaccination: Case report
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