What Do We Know about Nociplastic Pain?

被引:38
作者
Buldys, Kacper [1 ]
Gornicki, Tomasz [2 ]
Kalka, Dariusz [3 ,4 ]
Szuster, Ewa [5 ]
Biernikiewicz, Malgorzata [4 ]
Markuszewski, Leszek [1 ]
Sobieszczanska, Malgorzata [6 ]
机构
[1] Kazimierz Pulaski Univ Technol & Humanities Radom, Fac Med Sci & Hlth Sci, PL-26600 Radom, Poland
[2] Wroclaw Med Univ, Fac Med, PL-50367 Wroclaw, Poland
[3] Wroclaw Univ Hlth & Sport Sci, Fac Physiotherapy, PL-51612 Wroclaw, Poland
[4] Mens Hlth Ctr Wroclaw, PL-53151 Wroclaw, Poland
[5] Wroclaw Med Univ, Cardiosexol Students Club, PL-50368 Wroclaw, Poland
[6] Wroclaw Med Univ, Clin Dept Geriatr, PL-50369 Wroclaw, Poland
关键词
nociplastic pain; chronic pain; management; diagnosis; LOW-BACK-PAIN; ACHILLES TENDINOPATHY; CENTRAL SENSITIZATION; LEG PAIN; PALMITOYLETHANOLAMIDE; FIBROMYALGIA; UPDATE; SENSITIVITY; MECHANISMS; MANAGEMENT;
D O I
10.3390/healthcare11121794
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Nociplastic pain is a recently distinguished type of pain, distinct from neuropathic and nociceptive pain, and is well described in the literature. It is often mistaken for central sensitization. Pathophysiology has not been clearly established with regard to alteration of the concentration of spinal fluid elements, the structure of the white and gray matter of the brain, and psychological aspects. Many different diagnostic tools, i.e., the painDETECT and Douleur Neuropathique 4 questionnaires, have been developed to diagnose neuropathic pain, but they can also be applied for nociplastic pain; however, more standardized instruments are still needed in order to assess its occurrence and clinical presentation. Numerous studies have shown that nociplastic pain is present in many different diseases such as fibromyalgia, complex regional pain syndrome type 1, and irritable bowel syndrome. Current pharmacological and nonpharmacological treatments for nociceptive and neuropathic pain are not entirely suitable for treating nociplastic pain. There is an ongoing effort to establish the most efficient way to manage it. The significance of this field has led to several clinical trials being carried out in a short time. The aim of this narrative review was to discuss the currently available evidence on pathophysiology, associated diseases, treatment possibilities, and clinical trials. It is important that physicians widely discuss and acknowledge this relatively new concept in order to provide optimized pain control for patients.
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页数:14
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