Characteristic Hallmarks of Aging and the Impact on Carcinogenesis

被引：10

作者：

Terracina, Sergio ^{[1
]}

Ferraguti, Giampiero ^{[1
]}

Petrella, Carla ^{[2
]}

Bruno, Sabina Maria ^{[1
]}

Blacona, Giovanna ^{[1
]}

Di Certo, Maria Grazia ^{[2
]}

Minni, Antonio ^{[3
]}

Greco, Antonio ^{[3
]}

Musacchio, Angela ^{[3
]}

Ralli, Massimo ^{[3
]}

Tarani, Luigi ^{[4
]}

Ceccanti, Mauro ^{[5
]}

Polimeni, Antonella ^{[6
]}

Triaca, Viviana ^{[2
]}

Fiore, Marco ^{[2
,3
]}

机构：

[1] Sapienza Univ Rome, Dept Expt Med, Rome, Italy

[2] Natl Res Council IBBC CNR, Inst Biochem & Cell Biol, Rome, Italy

[3] Sapienza Univ Hosp Rome, Dept Sense Organs, Rome, Italy

[4] Sapienza Univ Rome, Dept Pediat, Rome, Italy

[5] SITAC Soc Italiana Trattamento Alcolismo & Compli, Rome, Italy

[6] Sapienza Univ Rome, Dept Odontostomatol & Maxillofacial Sci, Rome, Italy

来源：

CURRENT CANCER DRUG TARGETS | 2023年 / 23卷 / 02期

关键词：

Aging; cancer; epigenetic; genomic instability; microenvironment; oxidative stress; HEAT-SHOCK PROTEINS; SQUAMOUS-CELL CARCINOMA; NERVE GROWTH-FACTOR; MITOCHONDRIAL-DNA; EPIGENETIC MODIFICATIONS; TUMOR MICROENVIRONMENT; MACULAR DEGENERATION; OXIDATIVE DAMAGE; FACTOR VEGF; CANCER;

D O I：

10.2174/1568009622666220816120353

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Evidence shows that there is a synergistic, bidirectional association between cancer and aging with many shared traits. Age itself is a risk factor for the onset of most cancers, while evidence suggests that cancer and its treatments might accelerate aging by causing genotoxic and cytotoxic insults. Aging has been associated with a series of alterations that can be linked to cancer: i) genomic instability caused by DNA damage or epigenetic alterations coupled with repair errors, which lead to progressive accumulation of mutations; ii) telomere attrition with possible impairment of telomerase, shelterin complex, or the trimeric complex (Cdc13, Stn1 and Ten1 - CST) activities associated with abnormalities in DNA replication and repair; iii) altered proteostasis, especially when leading to an augmented proteasome, chaperon and autophagy-lysosome activity; iv) mitochondrial dysfunction causing oxidative stress; v) cellular senescence; vi) stem cells exhaustion, intercellular altered communication and deregulated nutrient sensing which are associated with microenvironmental modifications which may facilitate the subsequential role of cancer stem cells. Nowadays, anti-growth factor agents and epigenetic therapies seem to assume an increasing role in fighting aging-related diseases, especially cancer. This report aims to discuss the impact of age on cancer growth.

引用

页码：87 / 102

页数：16

共 200 条

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