Longitudinal Follow-Up of Serum and Urine Biomarkers Indicative of COVID-19-Associated Acute Kidney Injury: Diagnostic and Prognostic Impacts

被引:2
|
作者
Lablad, Yahya [1 ]
Vanhomwegen, Charlotte [1 ]
De Prez, Eric [1 ]
Antoine, Marie-Helene [1 ]
Hasan, Sania [1 ]
Baudoux, Thomas [1 ,2 ]
Nortier, Joelle [1 ]
机构
[1] Univ Libre Bruxelles, Fac Med, Lab Expt Nephrol, Erasme Campus,808 Route Lennik, B-1070 Brussels, Belgium
[2] Erasme Univ Hosp, Dept Nephrol Dialysis & Renal Transplantat, Erasme Campus, B-1070 Brussels, Belgium
关键词
AKI; COVID-19; biomarkers; NGAL; LAP; CCL14; cystatin C; suPAR; SOLUBLE UROKINASE RECEPTOR; COVID-19; PATIENTS;
D O I
10.3390/ijms242216495
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In patients hospitalized for severe COVID-19, the incidence of acute kidney injury (AKI) is approximately 40%. To predict and understand the implications of this complication, various blood and urine biomarkers have been proposed, including neutrophil gelatinase-associated lipocalin (NGAL), chemokine (C-C motif) ligand 14 (CCL14), cystatin C, leucine aminopeptidase (LAP), and soluble urokinase plasminogen activator (suPAR). This study, conducted between mid-January and early May 2021, aimed to assess the diagnostic and prognostic capabilities of these biomarkers in a cohort of COVID-19 patients monitored during the initial two weeks of hospitalization. Among the 116 patients included in this study, 48 developed AKI within the first three days of hospitalization (41%), with 29 requiring intensive care unit (ICU) admission, and the overall mortality rate was 18%. AKI patients exhibited a statistically significant increase in urinary LAP levels, indicating acute tubular injury as a potential mechanism underlying COVID-19-related renal damage. Conversely, urinary NGAL and CCL-14 excretion rates did not differ significantly between the AKI and non-AKI groups. Importantly, elevated plasma suPAR and cystatin C levels upon admission persisted throughout the first week of hospitalization and were associated with unfavorable outcomes, such as prolonged ICU stays and increased mortality, irrespective of AKI development. In conclusion, this study underscores the early predictive value of urinary LAP levels in identifying acute tubular injury in COVID-19-induced AKI. Moreover, elevated plasma suPAR and cystatin C levels serve as valuable prognostic markers, offering insights into the short-term morbidity and mortality risks among COVID-19 patients, regardless of AKI occurrence. These findings shed light on the complex interplay between COVID-19, renal injury, and biomarkers with diagnostic and prognostic potential.
引用
收藏
页数:12
相关论文
共 50 条
  • [1] COVID-19-Associated Acute Kidney Injury and Longitudinal Kidney Outcomes
    Aklilu, Abinet M.
    Kumar, Sanchit
    Nugent, James
    Yamamoto, Yu
    Coronel-Moreno, Claudia
    Kadhim, Bashar
    Faulkner, Sophia C.
    O'Connor, Kyle D.
    Yasmin, Farah
    Greenberg, Jason H.
    Moledina, Dennis G.
    Testani, Jeffrey M.
    Wilson, F. Perry
    JAMA INTERNAL MEDICINE, 2024, 184 (04) : 414 - 423
  • [2] Pathology of COVID-19-associated acute kidney injury
    Sharma, Purva
    Ng, Jia H.
    Bijol, Vanesa
    Jhaveri, Kenar D.
    Wanchoo, Rimda
    CLINICAL KIDNEY JOURNAL, 2021, 14 : 30 - 39
  • [3] Pathophysiology of COVID-19-associated acute kidney injury
    Legrand, Matthieu
    Bell, Samira
    Forni, Lui
    Joannidis, Michael
    Koyner, Jay L.
    Liu, Kathleen
    Cantaluppi, Vincenzo
    NATURE REVIEWS NEPHROLOGY, 2021, 17 (11) : 751 - 764
  • [4] COVID-19-Associated Acute Kidney Injury An Evolving Picture
    Siew, Edward D.
    Birkelo, Bethany C.
    CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2020, 15 (10): : 1383 - 1385
  • [5] Glomerular Endotheliosis in COVID-19-Associated Acute Kidney Injury
    Garay, Barbara
    Phachu, Deep
    Manickaratnam, Srimathi
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2022, 14 (07)
  • [6] COVID-19-associated coagulopathy and acute kidney injury in critically ill patients
    da Silva, Bruno Caldin
    Cordioli, Ricardo Luiz
    dos Santos, Bento Fortunato Cardoso
    Guerra, Joao Carlos de Campos
    Rodrigues, Roseny dos Reis
    de Souza, Guilherme Martins
    Ashihara, Carolina
    Midega, Thais Dias
    Campos, Niklas Soederberg
    Carneiro, Barbara Vieira
    Campos, Flavia Nunes Dias
    Guimaraes, Helio Penna
    de Matos, Gustavo Faissol Janot
    de Aranda, Valdir Fernandes
    Ferraz, Leonardo Jose Rolim
    Correa, Thiago Domingos
    EINSTEIN-SAO PAULO, 2023, 21 : eAO0119
  • [7] Catechins: Therapeutic Perspectives in COVID-19-Associated Acute Kidney Injury
    Leite Diniz, Lucio Ricardo
    Elshabrawy, Hatem A.
    de Santana Souza, Marilia Trindade
    Sucupira Duarte, Allana Brunna
    Datta, Sabarno
    de Sousa, Damiao Pergentino
    MOLECULES, 2021, 26 (19):
  • [8] Early prediction of COVID-19-associated acute kidney injury: Are serum NGAL and serum Cystatin C levels better than serum creatinine?
    Shakked, Naomi Pode
    Santos de Oliveira, Maria Helena
    Cheruiyot, Isaac
    Benoit, Justin L.
    Plebani, Mario
    Lippi, Giuseppe
    Benoit, Stefanie W.
    Henry, Brandon Michael
    CLINICAL BIOCHEMISTRY, 2022, 102 : 1 - 8
  • [9] The Role of Urinary Biomarkers as Diagnostic and Prognostic Predictors of Acute Kidney Injury Associated With Vancomycin
    Sampaio de Souza Garms, Durval
    Cardoso Eid, Karina Zanchetta
    Burdmann, Emmanuel A.
    Marcal, Lia Junqueira
    Antonangelo, Leila
    dos Santos, Adriano
    Ponce, Daniela
    FRONTIERS IN PHARMACOLOGY, 2021, 12
  • [10] COVID-19-Associated Acute Kidney Injury: Learning from the First Wave
    Wald, Ron
    Bagshaw, Sean M.
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2021, 32 (01): : 4 - 6