Lymph node metastasis in cancer progression: molecular mechanisms, clinical significance and therapeutic interventions

被引:90
作者
Ji, Haoran [1 ]
Hu, Chuang [1 ]
Yang, Xuhui [1 ]
Liu, Yuanhao [1 ]
Ji, Guangyu [1 ]
Ge, Shengfang [2 ]
Wang, Xiansong [1 ]
Wang, Mingsong [1 ]
机构
[1] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Thorac Surg, Shanghai Key Lab Tissue Engn,Sch Med, Shanghai 200011, Peoples R China
[2] Shanghai Jiao Tong Univ, Dept Ophthalmol, Shanghai Key Lab Orbital Dis & Ocular Oncol, Shanghai Peoples Hosp 9,Sch Med, Shanghai, Peoples R China
基金
中国国家自然科学基金;
关键词
CELL LUNG-CANCER; PAPILLARY THYROID-CARCINOMA; CENTRAL NECK DISSECTION; SURGICAL ADJUVANT BREAST; EORTC; 10981-22023; AMAROS; FATTY-ACID SYNTHASE; RECEPTOR T-CELLS; GROWTH-FACTOR-C; GASTRIC-CANCER; SENTINEL-NODE;
D O I
10.1038/s41392-023-01576-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Lymph nodes (LNs) are important hubs for metastatic cell arrest and growth, immune modulation, and secondary dissemination to distant sites through a series of mechanisms, and it has been proved that lymph node metastasis (LNM) is an essential prognostic indicator in many different types of cancer. Therefore, it is important for oncologists to understand the mechanisms of tumor cells to metastasize to LNs, as well as how LNM affects the prognosis and therapy of patients with cancer in order to provide patients with accurate disease assessment and effective treatment strategies. In recent years, with the updates in both basic and clinical studies on LNM and the application of advanced medical technologies, much progress has been made in the understanding of the mechanisms of LNM and the strategies for diagnosis and treatment of LNM. In this review, current knowledge of the anatomical and physiological characteristics of LNs, as well as the molecular mechanisms of LNM, are described. The clinical significance of LNM in different anatomical sites is summarized, including the roles of LNM playing in staging, prognostic prediction, and treatment selection for patients with various types of cancers. And the novel exploration and academic disputes of strategies for recognition, diagnosis, and therapeutic interventions of metastatic LNs are also discussed.
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页数:33
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