Risk factors for multiple sclerosis in the context of Epstein-Barr virus infection

被引：25

作者：

Hedstrom, Anna Karin ^{[1
]}

机构：

[1] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

关键词：

multiple sclerosis; Epstein-Barr virus; infectious mononucleosis; human leukocyte antigen; vitamin D; sun exposure; smoking; obesity; VITAMIN-D STATUS; BODY-MASS INDEX; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; NATURAL-KILLER-CELLS; T-CELLS; IMMUNE-RESPONSE; CYTOMEGALOVIRUS-SEROPOSITIVITY; ANTIBODY-TITERS; TOBACCO-SMOKE; SUN EXPOSURE;

D O I：

10.3389/fimmu.2023.1212676

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Compelling evidence indicates that Epstein Barr virus (EBV) infection is a prerequisite for multiple sclerosis (MS). The disease may arise from a complex interplay between latent EBV infection, genetic predisposition, and various environmental and lifestyle factors that negatively affect immune control of the infection. Evidence of gene-environment interactions and epigenetic modifications triggered by environmental factors in genetically susceptible individuals supports this view. This review gives a short introduction to EBV and host immunity and discusses evidence indicating EBV as a prerequisite for MS. The role of genetic and environmental risk factors, and their interactions, in MS pathogenesis is reviewed and put in the context of EBV infection. Finally, possible preventive measures are discussed based on the findings presented.

引用

页数：13

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