Anti-proliferative and anti-inflammatory activity of triterpene extracts from plant species belonging to Lamiaceae family

被引：3

作者：

Jordamovc, Nadir ^{[1
]}

Pehlivanovic, Belma ^{[2
]}

Niksic, Haris ^{[1
]}

Gusic, Irma ^{[1
]}

Koric, Emina ^{[1
]}

Dedic, Mirza ^{[3
]}

Tuna-Repovac, Belma ^{[4
]}

Becic, Fahir ^{[2
]}

Duric, Kemal ^{[1
]}

机构：

[1] Univ Sarajevo, Fac Pharm, Dept Pharmacognosy, Zmaja Bosne 33-35, Sarajevo, Bosnia & Herceg

[2] Univ Sarajevo, Fac Pharm, Dept Pharmacol & Clin Pharm, Zmaja Bosne 33-35, Sarajevo, Bosnia & Herceg

[3] Univ Sarajevo, Fac Pharm, Dept Drug Analyt, Zmaja Bosne 33-35, Sarajevo, Bosnia & Herceg

[4] Pharm Monis, Franca Lehara 2, Sarajevo, Bosnia & Herceg

来源：

BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS | 2023年 / 22卷 / 06期

关键词：

Anti-proliferative; Anti-inflammatory; Triterpenes; Lamiaceae family; Rosmarinus officinalis; BETULINIC ACID; OLEANOLIC ACID; MOLECULAR-MECHANISMS; CELL-CYCLE; CANCER; DERIVATIVES; CARCINOMA; CYTOTOXICITY; LUPEOL; GROWTH;

D O I：

10.37360/blacpma.23.22.6.58

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Triterpenes are very important secondary metabolites with wide structural diversity and significant role in pharmacy and medicine. In the present research, a comparative study of pharamacological activities of the triterpene fractions obtained from several plant species belonging to Lamiaceae family, was carried out. In-vitro anti-proliferative activity was performed using a standard proliferation assay based on tetrazolium salts. In vitro anti-inflammatory activity of triterpene fractions was determined by an assay of inhibition of albumin denaturation. In general, the triterpene fractions obtained from plant species belonging to Lamiaceae family showed a strong anti-proliferative activity and anti-inflammatory activity. The triterpene fraction of Rosmarini folium showed the strongest anti -proliferative activity (GI50 range from 4 to 37 & mu;g/ml) and the strongest anti-inflammatory activity in the range from 57.27% to 80.69%. This comparative study provides scientific evidence to support the traditional use of Lamiacae plant species for medical purposes as anti-inflammatory and anti-proliferative medicines.

引用

页码：864 / 878

页数：15

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