Lignan intake and risk of cardiovascular disease and type 2 diabetes: a meta-analysis of prospective cohort studies

被引：7

作者：

Xia, Meng ^{[1
]}

Chen, Yujin ^{[1
]}

Li, Wei ^{[2
]}

Qian, Cheng ^{[1
,3
]}

机构：

[1] Southwest Med Univ, Dept Cardiol, Affiliated Hosp, Luzhou, Sichuan, Peoples R China

[2] Cent Hosp Enshi Tujia & Miao Autonomous Prefecture, Dept Pathol, Enshi, Hubei, Peoples R China

[3] Southwest Med Univ, Dept cardiol, Affiliated Hosp, 25 Taiping St, Luzhou, Sichuan, Peoples R China

来源：

INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION | 2023年 / 74卷 / 04期

关键词：

Lignan; cardiovascular disease; type 2 diabetes mellitus; meta-analysis; prevention; DIETARY POLYPHENOL INTAKE; TREND ESTIMATION; ASSOCIATION; MORTALITY;

D O I：

10.1080/09637486.2023.2220985

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

We conducted a meta-analysis of 12 prospective cohort studies to further illuminate the associations of lignan intake with risk of cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). Compared with the lowest intake, the highest intake of lignans was correlated with a decreased incidence of CVD (relative risk [RR]: 0.85, 95% confidence interval [CI]: 0.80-0.90) and T2DM (RR: 0.82, 95% CI: 0.68-0.99). The benefits of lignan intake in CVD prevention were consistent across subgroups. In dose-response analysis, the RR for every 500-mu g/d increment in lignan intake was 0.83 (95% CI: 0.74-0.92) for CVD and 0.96 (95% CI: 0.95-0.98) for T2DM. Moreover, a curvilinear dose-response pattern was observed for both CVD (p for nonlinearity < 0.001) and T2DM (p for nonlinearity < 0.001) in relation to lignan intake. These results indicated that higher lignan intake may be associated, in a dose-dependent manner, with a lower risk of CVD and T2DM.

引用

页码：501 / 509

页数：9

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