Hi-C, a chromatin 3D structure technique advancing the functional genomics of immune cells

被引：3

作者：

Liu, Ran ^{[1
]}

Xu, Ruitang ^{[1
]}

Yan, Siyu ^{[1
]}

Li, Peiyu ^{[1
]}

Jia, Changteng ^{[1
]}

Sun, Haoqiang ^{[1
]}

Sheng, Kaiwen ^{[1
]}

Wang, Yongjie ^{[1
]}

Zhang, Qi ^{[1
]}

Guo, Jiao ^{[1
]}

Xin, Xiangzheng ^{[1
]}

Li, Xinlan ^{[1
]}

Guo, Dianhao ^{[1
]}

机构：

[1] Shandong First Med Univ & Shandong Acad Med Sci, Sch Clin & Basic Med Sci, Jinan, Shandong, Peoples R China

来源：

FRONTIERS IN GENETICS | 2024年 / 15卷

关键词：

3D chromatin structure; Hi-C; immune cells; regulation of gene expression; diseases; CHROMOSOME CONFORMATION CAPTURE; DOMAINS; CONTRIBUTES; IDENTIFICATION; TRANSCRIPTION; ORGANIZATION; ARCHITECTURE; ACTIVATION; PRINCIPLES; ENHANCERS;

D O I：

10.3389/fgene.2024.1377238

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The functional performance of immune cells relies on a complex transcriptional regulatory network. The three-dimensional structure of chromatin can affect chromatin status and gene expression patterns, and plays an important regulatory role in gene transcription. Currently available techniques for studying chromatin spatial structure include chromatin conformation capture techniques and their derivatives, chromatin accessibility sequencing techniques, and others. Additionally, the recently emerged deep learning technology can be utilized as a tool to enhance the analysis of data. In this review, we elucidate the definition and significance of the three-dimensional chromatin structure, summarize the technologies available for studying it, and describe the research progress on the chromatin spatial structure of dendritic cells, macrophages, T cells, B cells, and neutrophils.

引用

页数：14

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