Rosacea: Pathogenesis and Therapeutic Correlates

被引：26

作者：

Geng, Ryan S. Q. ^{[1
,5
]}

Bourkas, Adrienn N. ^{[2
]}

Mufti, Asfandyar ^{[3
]}

Sibbald, R. Gary ^{[1
,3
,4
]}

机构：

[1] Univ Toronto, Temerty Sch Med, Toronto, ON, Canada

[2] Queens Univ, Sch Med, Kingston, ON, Canada

[3] Univ Toronto, Dept Med, Div Dermatol, Toronto, ON, Canada

[4] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada

[5] Univ Toronto, Temerty Sch Med, Med Sci Bldg, 1 Kings Coll Cir, Toronto, ON M5S 1A8, Canada

来源：

JOURNAL OF CUTANEOUS MEDICINE AND SURGERY | 2024年 / 28卷 / 02期

关键词：

rosacea; pathogenesis; treatment; SERINE-PROTEASE ACTIVITY; HELICOBACTER-PYLORI; SKIN INFLAMMATION; IVERMECTIN; 1-PERCENT; DOUBLE-BLIND; MAST-CELLS; CATHELICIDIN; METRONIDAZOLE; LL-37; ACTIVATION;

D O I：

10.1177/12034754241229365

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Rosacea is a chronic inflammatory condition of which there is no cure. The pathogenesis of rosacea is likely multifactorial, involving genetic and environmental contributions. Current understanding suggests that pro-inflammatory pathways involving cathelicidins and inflammasome complexes are central to rosacea pathogenesis. Common rosacea triggers modulate these pathways in a complex manner, which may contribute to the varying severity and clinical presentations of rosacea. Established and emerging rosacea treatments may owe their efficacy to their ability to target different players in these pro-inflammatory pathways. Improving our molecular understanding of rosacea will guide the development of new therapies and the use of combination therapies.

引用

页码：178 / 189

页数：12

共 99 条

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