Integrating subvolume dose and myocardial perfusion imaging parameters to assess the impact of radiation therapy on heart function in breast cancer patients: A comparative analysis between left- and right-sided breast cancer

被引：0

作者：

Wang, Shan-Ying ^{[1
,2
]}

Tsai, Wei-Ta ^{[1
,3
]}

Lin, Kuan-Heng ^{[1
,4
,5
]}

Yu, Chih-Wei ^{[6
,7
]}

Yang, Shu-Ya ^{[8
]}

Shueng, Pei-Wei ^{[4
,9
]}

Wu, Yen-Wen ^{[2
,9
,10
]}

Hsu, Chen-Xiong ^{[1
,4
,11
]}

Wu, Tung-Hsin ^{[1
]}

机构：

[1] Natl Yang Ming Chiao Tung Univ, Dept Biomed Imaging & Radiol Sci, Taipei, Taiwan

[2] Far Eastern Mem Hosp, Dept Nucl Med, New Taipei, Taiwan

[3] Dalin Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Radiat Oncol, Chiayi, Taiwan

[4] Far Eastern Mem Hosp, Dept Radiol, Div Radiat Oncol, New Taipei, Taiwan

[5] Natl Yang Ming Chiao Tung Univ, Ind Ph D Program Biomed Sci & Engn, Taipei, Taiwan

[6] China Med Univ, Dept Radiat Oncol, Hsinchu Hosp, Zhubei City, Taiwan

[7] Natl Tsing Hua Univ, Inst Nucl Engn & Sci, Hsinchu, Taiwan

[8] Cheng Hsin Gen Hosp, Dept Nucl Med, Taipei, Taiwan

[9] Natl Yang Ming Chiao Tung Univ, Coll Med, Sch Med, Taipei, Taiwan

[10] Far Eastern Mem Hosp, Cardiovasc Med Ctr, Div Cardiol, New Taipei, Taiwan

[11] Far Eastern Mem Hosp, Div Radiat Oncol, New Taipei, Taiwan

来源：

THORACIC CANCER | 2023年 / 14卷 / 26期

关键词：

myocardial perfusion imaging; subvolume dose; radiation therapy; CORONARY-ARTERY-DISEASE; CARDIAC DYSFUNCTION; RADIOTHERAPY; RISK; CHEMOTHERAPY; IRRADIATION; TOXICITY; TRACKING; DEFECTS; MOTION;

D O I：

10.1111/1759-7714.15056

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: This study aimed to utilize an innovative method of integrating the 20 subvolume dose of left ventricle and the Tl-201 single photon emission computed tomography (SPECT) with myocardial perfusion imaging (MPI) parameters in patients with left- and right-sided breast cancer after radiation therapy.Methods: Female patients with breast cancer underwent SPECT MPI before commencing radiotherapy and 12 months later were enrolled from January 2014 to December 2018. The images of CT simulation and SPECT MPI were integrated into the treatment planning system. The differences of doses and parameters of MPI in all cardiac subvolumes between left- and right-sided breast cancer patients were analyzed.Results: Patients with left-sided breast cancer (n = 61) received a higher radiation dose to the heart, left ventricular, and its territories and subvolumes, compared to patients with right-sided breast cancer (n = 19). The 20-segment analysis also showed statistically significant disparities in the average radiation doses received by the two groups. In different coronary artery territories, the end-diastolic perfusion and end-systolic perfusion showed a decrease in both sides, with no significant differences. However, the wall motion and wall thickening showed a significant decline in subregions within the left- and right-sided coronary artery territories.Conclusion: This study demonstrates an innovative integrated method combining the left ventricular 20 regional doses with SPECT MPI which shows that left-sided breast cancer patients receive a higher subvolume dose than right-sided breast cancer patients. Further research is needed to confirm the potential impact on heart function after radiotherapy on both sides.

引用

页码：2696 / 2706

页数：11

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