N-Acetylcysteine encapsulated niosomes as antitumor nanoparticles

被引：1

作者：

Ashraf, Abeer ^{[1
]}

El-Gebaly, Reem H. ^{[1
]}

Mohamad, Ebtesam A. ^{[1
]}

机构：

[1] Cairo Univ, Fac Sci, Biophys Dept, Cairo, Egypt

来源：

EGYPTIAN JOURNAL OF CHEMISTRY | 2023年 / 66卷 / 05期

关键词：

Niosomes; N-Acetylcysteine; Tumor; Histopathology; CARBOPLATIN;

D O I：

10.21608/ejchem.2022.155918.6745

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

N-Acetylcysteine (NAC) is an antioxidant compound with antitumor properties. In this study NAC was encapsulated into niosomes for treatment tumor in mice. NAC- encapsulated niosomes' morphology and Fourier-transform infrared spectroscopy (FTIR) analysis were measured. Fifteen mice male BALB/c were divided to three groups: group1: negative control, group2 positive control (tumor group), group3 treated with NAC- encapsulated niosomes after tumor growth. The effect of NAC- encapsulated niosomes on the tumor was determined by measuring tumor size progress, comet assay, examination found that NAC- encapsulated niosomes have spherical shape. Tissues histological studies emphasized the protective effect of NAC- encapsulated niosomes against tumor. In conclusion oral delivery of NAC- encapsulated niosomes improved antitumor effect.

引用

页码：379 / 384

页数：6

共 36 条

[1] Enhancement of mechanical properties of chitosan film by doping with sage extract-loaded niosomes [J].