Review deciphering potent therapeutic approaches targeting Notch signaling pathway in breast cancer

被引：11

作者：

Pandey, Pratibha ^{[1
]}

Khan, Fahad ^{[1
]}

Choi, Min ^{[2
,3
]}

Singh, Sujeet Kumar ^{[1
]}

Kang, Han Na ^{[4
]}

Park, Moon Nyeo ^{[2
,3
]}

Ko, Seong-Gyu ^{[3
]}

Sahu, Sanjeev Kumar ^{[5
]}

Mazumder, Rupa ^{[6
]}

Kim, Bonglee ^{[2
,3
]}

机构：

[1] Noida Inst Engn & Technol, Dept Biotechnol, Greater Noida 201306, India

[2] Kyung Hee Univ, Coll Korean Med, Dept Pathol, Hoegidong Dongdaemun Gu, Seoul 02447, South Korea

[3] Kyung Hee Univ, Coll Korean Med, Korean Med Based Drug Repositioning Canc Res Ctr, Seoul 02447, South Korea

[4] Korea Inst Oriental Med, KM Convergence Res Div, Daejeon, South Korea

[5] Lovely Profess Univ, Sch pharmaceut Sci, Phagwara, Punjab, India

[6] Noida Inst Engn & Technol, Pharm Inst, Greater Noida 201306, India

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 164卷

基金：

新加坡国家研究基金会;

关键词：

Notch signaling pathway; Breast cancer; Natural compounds; Targeted therapeutics; Nanoparticles; DEVELOPMENTAL PATHWAYS; DOWN-REGULATION; STEM-CELLS; METASTASIS; INHIBITION; NANOPARTICLES; COMBINATION; PROGRESSION; MICRORNA; MIR-200B;

D O I：

10.1016/j.biopha.2023.114938

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In the current period of drug development, natural products have provided an unrivaled supply of anticancer medications. By modifying the cancer microenvironment and various signaling pathways, natural products and their derivatives and analogs play a significant role in cancer treatment. These substances are effective against several signaling pathways, particularly the cell death pathways (apoptosis and autophagy) and embryonic developmental pathways (Notch, Wnt, and Hedgehog pathways). Natural products have a long history, but more research is needed to understand their current function in the research and development of cancer treatments and the potential for natural products to serve as a significant source of therapeutic agents in the future. Several target-specific anticancer medications failed to treat cancer, necessitating research into natural compounds with multiple target properties. To help develop a better treatment plan for managing breast cancer, this review has outlined the anticancerous potential of several therapeutic approaches targeting the notch signaling system in breast tumors.

引用

页数：12

共 89 条

[1] Modulation of Cancer and Stem Cell Biomarkers by the Notch Inhibitor MK-0752 Added to Endocrine Therapy for Early Stage ER plus Breast Cancer. [J].

Albain, K. S. ;

Czerlanis, C. ;

Zlobin, A. ;

Covington, K. R. ;

Rajan, P. ;

Godellas, C. ;

Bova, D. ;

Lo, S. S. ;

Robinson, P. ;

Sarker, S. ;

Gaynor, E. R. ;

Cooper, R. ;

Aranha, G. ;

Czaplicki, K. ;

Busby, B. ;

Rizzo, P. ;

Demuth, T. ;

Stiff, P. ;

Fuqua, S. A. W. ;

Miele, L. .

CANCER RESEARCH, 2011, 71

[2] A Review on Targeting Nanoparticles for Breast Cancer [J].

Alqaraghuli, Hasanain Gomhor J. ;

Kashanian, Soheila ;

Rafipour, Ronak .

CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2019, 20 (13) :1087-1107

[3] Downregulation of STAT3, β-Catenin, and Notch-1 by Single and Combinations of siRNA Treatment Enhance Chemosensitivity of Wild Type and Doxorubicin Resistant MCF7 Breast Cancer Cells to Doxorubicin [J].

Alshaer, Walhan ;

Alqudah, Dana A. ;

Wehaibi, Suha ;

Abuarqoub, Duaa ;

Zihlif, Malek ;

Hatmal, Ma'mon M. ;

Awidi, Abdalla .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (15)

[4] 6-Shogaol suppresses the growth of breast cancer cells by inducing apoptosis and suppressing autophagy via targeting notch signaling pathway [J].

Bawadood, Azizah S. ;

Al-Abbasi, Fahad A. ;

Anwar, Firoz ;

El-Halawany, Ali M. ;

Al-Abd, Ahmed M. .

BIOMEDICINE & PHARMACOTHERAPY, 2020, 128

[5]

Bhavana V., 2022, Targeted Nanomedicine for Breast Cancer Therapy, P281, DOI DOI 10.1016/B978-0-12-824476-0.00006-1

[6] Positive feedback loop between mitochondrial fission and Notch signaling promotes survivin-mediated survival of TNBC cells [J].

Chen, Li ;

Zhang, Jing ;

Lyu, Zhuomin ;

Chen, Yibing ;

Ji, Xiaoying ;

Cao, Haiyan ;

Jin, Mingpeng ;

Zhu, Jianjun ;

Yang, Jin ;

Ling, Rui ;

Xing, Jinliang ;

Ren, Tingting ;

Lyu, Yonggang .

CELL DEATH & DISEASE, 2018, 9

[7] Mammary Development and Breast Cancer: a Notch Perspective [J].

Chen, Weizhen ;

Wei, Wei ;

Yu, Liya ;

Ye, Zi ;

Huang, Fujing ;

Zhang, Liyan ;

Hu, Shiqi ;

Cai, Cheguo .

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 2021, 26 (03) :309-320

[8]

Cheng JZ, 2016, SCI REP-UK, V6, DOI [10.1038/srep24454, 10.1038/srep25671]

[9] Cyclin D1 is a direct target of JAG1-mediated Notch signaling in breast cancer [J].

Cohen, Brenda ;

Shimizu, Mamiko ;

Izrailit, Julia ;

Ng, Nancy F. L. ;

Buchman, Yuri ;

Pan, James G. ;

Dering, Judy ;

Reedijk, Michael .

BREAST CANCER RESEARCH AND TREATMENT, 2010, 123 (01) :113-124

[10]

Dana Hassan, 2017, Int J Biomed Sci, V13, P48

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