Cartilage Tissue Engineering in Practice: Preclinical Trials, Clinical Applications, and Prospects

Impact statementThis review focuses on advances in cartilage tissue engineering, particularly in practices, challenges, and prospects of preclinical trials and clinical applications. Articular cartilage defects significantly compromise the quality of life in the global population. Although many strategies are needed to repair articular cartilage, including microfracture, autologous osteochondral transplantation, and osteochondral allograft, the therapeutic effects remain suboptimal. In recent years, with the development of cartilage tissue engineering, scientists have continuously improved the formulations of therapeutic cells, biomaterial-based scaffolds, and biological factors, which have opened new avenues for better therapeutics of cartilage lesions. This review focuses on advances in cartilage tissue engineering, particularly in preclinical trials and clinical applications, prospects, and challenges.