Nanomaterials for antigen-specific immune tolerance therapy

被引:12
作者
Park, Jinwon [1 ,2 ]
Wu, Yina [1 ,2 ]
Li, Qiaoyun [1 ,2 ]
Choi, Jaehyun [1 ,2 ]
Ju, Hyemin [1 ,2 ]
Cai, Yu [3 ]
Lee, Jaiwoo [1 ,2 ]
Oh, Yu-Kyoung [1 ,2 ]
机构
[1] Seoul Natl Univ, Coll Pharm, Seoul 08826, South Korea
[2] Seoul Natl Univ, Res Inst Pharmaceut Sci, Seoul 08826, South Korea
[3] Jinan Univ, Coll Pharm, Guangzhou 510632, Peoples R China
基金
新加坡国家研究基金会;
关键词
Tolerogenic vaccine; Nanomaterials; Nanoparticles; Autoimmune disease; Allergic disease; REGULATORY T-CELLS; ALLERGEN-SPECIFIC IMMUNOTHERAPY; TOLEROGENIC DENDRITIC CELLS; MULTIPLE-SCLEROSIS; CARBON NANOTUBES; FOOD ALLERGY; MECHANISMS; RESPONSES; ASTHMA; INFLAMMATION;
D O I
10.1007/s13346-022-01233-3
中图分类号
TH7 [仪器、仪表];
学科分类号
0804 ; 080401 ; 081102 ;
摘要
Impairment of immune tolerance might cause autologous tissue damage or overactive immune response against non-pathogenic molecules. Although autoimmune disease and allergy have complicated pathologies, the current strategies have mainly focused on symptom amelioration or systemic immunosuppression which can lead to fatal adverse events. The induction of antigen-specific immune tolerance may provide therapeutic benefits to autoimmune disease and allergic response, while reducing nonspecific immune adverse responses. Diverse nanomaterials have been studied to induce antigen-specific immune tolerance therapy. This review will cover the immunological background of antigen-specific tolerance, clinical importance of antigen-specific immune tolerance, and nanomaterials designed for autoimmune and allergic diseases. As nanomaterials for modulating immune tolerances, lipid-based nanoparticles, polymeric nanoparticles, and biological carriers have been covered. Strategies to provide antigen-specific immune tolerance have been addressed. Finally, current challenges and perspectives of nanomaterials for antigen-specific immune tolerance therapy will be discussed.
引用
收藏
页码:1859 / 1881
页数:23
相关论文
共 173 条
[81]   Dendritic cells in Th2 immune responses and allergic sensitization [J].
Lamiable, Olivier ;
Mayer, Johannes U. ;
Munoz-Erazo, Luis ;
Ronchese, Franca .
IMMUNOLOGY AND CELL BIOLOGY, 2020, 98 (10) :807-818
[82]   Immunological mechanisms of allergen-specific immunotherapy [J].
Larche, Mark ;
Akdis, Cezmi A. ;
Valenta, Rudolf .
NATURE REVIEWS IMMUNOLOGY, 2006, 6 (10) :761-771
[83]   Reactive oxygen species-responsive dendritic cell-derived exosomes for rheumatoid arthritis [J].
Lee, Eun Sook ;
Sul, Jae Hoon ;
Shin, Jung Min ;
Shin, Sol ;
Lee, Jae Ah ;
Kim, Hark Kyun ;
Cho, Yongeun ;
Ko, Hyewon ;
Son, Soyoung ;
Lee, Jeongmi ;
Park, Sunyoung ;
Jo, Dong-Gyu ;
Park, Jae Hyung .
ACTA BIOMATERIALIA, 2021, 128 :462-473
[84]   Metabolic and immunomodulatory control of type 1 diabetes via orally delivered bile-acid-polymer nanocarriers of insulin or rapamycin [J].
Lee, Jung Seok ;
Han, Patrick ;
Chaudhury, Rabib ;
Khan, Shihan ;
Bickerton, Sean ;
McHugh, Michael D. ;
Park, Hyun Bong ;
Siefert, Alyssa L. ;
Rea, Gerald ;
Carballido, Jose M. ;
Horwitz, David A. ;
Criscione, Jason ;
Perica, Karlo ;
Samstein, Robert ;
Rageb, Ragy ;
Kim, Dongin ;
Fahmy, Tarek M. .
NATURE BIOMEDICAL ENGINEERING, 2021, 5 (09) :983-997
[85]   Nanoparticles in the Treatment of Infections Caused by Multidrug-Resistant Organisms [J].
Lee, Nan-Yao ;
Ko, Wen-Chien ;
Hsueh, Po-Ren .
FRONTIERS IN PHARMACOLOGY, 2019, 10
[86]   Immune cell crosstalk in type 1 diabetes [J].
Lehuen, Agnes ;
Diana, Julien ;
Zaccone, Paola ;
Cooke, Anne .
NATURE REVIEWS IMMUNOLOGY, 2010, 10 (07) :501-513
[87]   Dual-Sized Microparticle System for Generating Suppressive Dendritic Cells Prevents and Reverses Type 1 Diabetes in the Nonobese Diabetic Mouse Model [J].
Lewis, Jamal S. ;
Stewart, Joshua M. ;
Marsha, Gregory P. ;
Carstens, Matthew R. ;
Zhang, Ying ;
Dolgoya, Natalia, V ;
Xia, Changqing ;
Brusko, Todd M. ;
Wasserfall, Clive H. ;
Clare-Salzler, Michael J. ;
Atkinson, Mark A. ;
Keselowsky, Benjamin G. .
ACS BIOMATERIALS SCIENCE & ENGINEERING, 2019, 5 (05) :2631-2646
[88]   A Chromatin-Mimetic Nanomedicine for Therapeutic Tolerance Induction [J].
Li, Bowen ;
Yuan, Zhefan ;
McMullen, Patrick ;
Xie, Jingyi ;
Jain, Priyesh ;
Hung, Hsiang-Chieh ;
Xu, Shihan ;
Zhang, Peng ;
Lin, Xiaojie ;
Wu, Kan ;
Jiang, Shaoyi .
ACS NANO, 2018, 12 (12) :12004-12014
[89]   Nanoemulsions Target to Ectopic Lymphoids in Inflamed Joints to Restore Immune Tolerance in Rheumatoid Arthritis [J].
Li, Chenglong ;
Chen, Xiaoyan ;
Luo, Xianjin ;
Wang, Hairui ;
Zhu, Yining ;
Du, Guangshen ;
Chen, Wenfei ;
Chen, Zhengjun ;
Hao, Xinyan ;
Zhang, Zhirong ;
Sun, Xun .
NANO LETTERS, 2021, 21 (06) :2551-2561
[90]   Role of Toll-Like Receptors in Neuroimmune Diseases: Therapeutic Targets and Problems [J].
Li, Haixia ;
Liu, Shan ;
Han, Jinming ;
Li, Shengxian ;
Gao, Xiaoyan ;
Wang, Meng ;
Zhu, Jie ;
Jin, Tao .
FRONTIERS IN IMMUNOLOGY, 2021, 12