Advances in pathogenesis of preeclampsia

被引：21
作者：
Yang, Mei [1 ]
Wang, Menghui [1 ]
Li, Nanfang [1 ]
机构：
[1] Hypertens Ctr Peoples Hosp, Xinjiang Clin Med Res Ctr Hypertens Cardio Cerebro, Xinjiang Hypertens Inst,NHC Key Lab Hypertens Clin, Key Lab Xinjiang Uygur Autonomous Reg Hypertens Re, 91 TianChi Rd, Urumqi 830001, Xinjiang, Peoples R China
来源：
ARCHIVES OF GYNECOLOGY AND OBSTETRICS | 2024年 / 309卷 / 05期
关键词：
Preeclampsia; Uteroplacental hypoxia; Angiogenesis; Epigenetic regulation; Gut microbiota; RECEPTOR AGONISTIC AUTOANTIBODIES; SOLUBLE ENDOGLIN; NORMAL-PREGNANCY; BIOMARKERS; INVASION; RISK; IDENTIFICATION; HYPERTENSION; ACTIVATION; CARCINOMA;
D O I：
10.1007/s00404-024-07393-6
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
PurposePreeclampsia is a major cause of health problems for both pregnant women and unborn babies worldwide. However, the underlying causes of preeclampsia are not fully understood, leading to limited effective treatments. The goal of this study is to enhance our knowledge of its causes, devise prevention strategies, and develop treatments.MethodsWe performed a systematic literature search. Six models regarding the pathogenesis of preeclampsia are discussed in this review.ResultsThis review focuses on the latest advancements in understanding preeclampsia's origins. Preeclampsia is a complex condition caused by various factors, processes, and pathways. Reduced blood flow and oxygen to the uterus and placenta, heightened inflammatory reactions, immune imbalances, altered genetic changes, imbalanced blood vessel growth factors, and disrupted gut bacteria may contribute to its development.ConclusionPreeclampsia is thought to result from the interplay of these factors.
引用
收藏
页码：1815 / 1823
页数：9
相关论文
共 50 条
[41]   The additive role of angiogenic markers for women with confirmed preeclampsia [J].
Suresh, Sunitha ;
Patel, Easha ;
Mueller, Ariel ;
Morgan, Jessica ;
Lewandowski, Whitney Lynn ;
Verlohren, Stefan ;
Dadelszen, Peter von ;
Magee, Laura A. ;
Rana, Sarosh .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2023, 228 (05) :573.e1-573.e11
[42]   The role of endoglin and its soluble form in pathogenesis of preeclampsia [J].
Georgia Margioula-Siarkou ;
Chrysoula Margioula-Siarkou ;
Stamatios Petousis ;
Kosmas Margaritis ;
Eleftherios Vavoulidis ;
Giuseppe Gullo ;
Maria Alexandratou ;
Konstantinos Dinas ;
Alexandros Sotiriadis ;
Georgios Mavromatidis .
Molecular and Cellular Biochemistry, 2022, 477 :479-491
[43]   Role of activin A in the pathogenesis of endothelial cell dysfunction in preeclampsia [J].
Hobson, Sebastian R. ;
Acharya, Rutu ;
Lim, Rebecca ;
Chan, Siow Teng ;
Mockler, Joanne ;
Wallace, Euan M. .
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH, 2016, 6 (02) :130-133
[44]   Angiogenic factors in the pathogenesis and pathophysiology of preeclampsia: A Mini review [J].
Yelumalai, Suseela ;
Subramanian, Kaviarasan ;
Omar, Siti Zawiah ;
Qvist, Rajes ;
Muniandy, Sekaran .
BIOMEDICAL RESEARCH-INDIA, 2010, 21 (03) :246-251
[45]   The role of endoglin and its soluble form in pathogenesis of preeclampsia [J].
Margioula-Siarkou, Georgia ;
Margioula-Siarkou, Chrysoula ;
Petousis, Stamatios ;
Margaritis, Kosmas ;
Vavoulidis, Eleftherios ;
Gullo, Giuseppe ;
Alexandratou, Maria ;
Dinas, Konstantinos ;
Sotiriadis, Alexandros ;
Mavromatidis, Georgios .
MOLECULAR AND CELLULAR BIOCHEMISTRY, 2022, 477 (02) :479-491
[46]   A potential role for free fatty acids in the pathogenesis of preeclampsia [J].
Robinson, Nicola J. ;
Minchell, Laura J. ;
Myers, Jenny E. ;
Hubel, Carl A. ;
Crocker, Ian P. .
JOURNAL OF HYPERTENSION, 2009, 27 (06) :1293-1302
[47]   Matrix Metalloproteinases and Its Inhibitors: the Role in the Pathogenesis of Preeclampsia [J].
Aksenenko, V. A. ;
Dubovoy, A. A. ;
Androsova, O. V. .
18TH WORLD CONGRESS ON CONTROVERSIES IN OBSTETRICS, GYNECOLOGY & INFERTILITY (COGI), 2014, :129-134
[48]   Relevance of MicroRNA-122 to pathogenesis of preeclampsia in rats [J].
Bai, Yun ;
Zhang, Xiaoxia ;
Yang, Xia ;
Li, Fengling .
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2017, 10 (07) :10103-10112
[49]   The Role of Adenomyosis in the Pathogenesis of Preeclampsia [J].
Hasdemir, P. S. ;
Farasat, M. ;
Aydin, C. ;
Ozyurt, B. C. ;
Guvenal, T. ;
Pekindil, G. .
GEBURTSHILFE UND FRAUENHEILKUNDE, 2016, 76 (08) :882-887
[50]   Is thrombin a "toxin" in the pathogenesis of preeclampsia? [J].
Sugimura, Motoi .
HYPERTENSION RESEARCH IN PREGNANCY, 2015, 3 (01) :13-18
12345