Wind-tunnel modeling of Atmospheric Boundary Layer flows has primarily consisted of simplified (purely uniform) upwind terrain conditions. This approach is easier to carry out but may not replicate the true wind characteristics of the site. This paper proposes a method to simulate nonuniform terrains in a wind-tunnel and investigates the wind characteristics produced by the method. The proposed method employs the local roughness zones where the given terrain is divided into sub-areas with an approximately uniform roughness length. Next, each sub-area is represented in the wind-tunnel with uniform roughness elements. However, the overall upwind fetch will be composed of roughness elements of various heights. To study the wind characteristics produced by the method, nine different real-world sites were simulated in the Boundary Layer Wind Tunnel at the University of Florida Natural Hazard Engineering Infrastructure Experimental Facility, using a self-configurable (automated) roughness element grid. Compared with the conventional equivalent uniform representation, similarities and differences in the longitudinal mean velocity, turbulence intensity, wind spectrum, and integral length scale profiles are reported and discussed. In particular, a significant difference was observed for the higher-order moments of the longitudinal velocity component, which indicates the need for further studies in wind loads under nonuniform terrains.