Regulation of the renin-angiotensin-aldosterone system by cyclic nucleotides and phosphodiesterases

被引：4
作者：
Gambaryan, Stepan [1 ]
Mohagaonkar, Sanika [2 ,3 ]
Nikolaev, Viacheslav O. [2 ,3 ]
机构：
[1] Russian Acad Sci, Sechenov Inst Evolutionary Physiol & Biochem, St Petersburg, Russia
[2] Univ Med Ctr Hamburg Eppendorf, Inst Expt Cardiovasc Res, Hamburg, Germany
[3] German Ctr Cardiovasc Res DZHK, Partner Site Hamburg Kiel Lubeck, Hamburg, Germany
来源：
FRONTIERS IN ENDOCRINOLOGY | 2023年 / 14卷
关键词：
cAMP; cGMP; phosphodiesterase; renin; aldosterone; NITRIC-OXIDE SYNTHASE; ADRENAL GLOMERULOSA CELLS; ATRIAL-NATRIURETIC-FACTOR; DEPENDENT PROTEIN-KINASE; ZONA GLOMERULOSA; GENE-TRANSCRIPTION; JUXTAGLOMERULAR CELLS; ADENYLATE-CYCLASE; HUMAN PLATELETS; MESSENGER-RNA;
D O I：
10.3389/fendo.2023.1239492
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The renin-angiotensin-aldosterone system (RAAS) is one of the key players in the regulation of blood volume and blood pressure. Dysfunction of this system is connected with cardiovascular and renal diseases. Regulation of RAAS is under the control of multiple intracellular mechanisms. Cyclic nucleotides and phosphodiesterases are the major regulators of this system since they control expression and activity of renin and aldosterone. In this review, we summarize known mechanisms by which cyclic nucleotides and phosphodiesterases regulate renin gene expression, secretion of renin granules from juxtaglomerular cells and aldosterone production from zona glomerulosa cells of adrenal gland. We also discuss several open questions which deserve future attention.
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页数：11
相关论文
共 122 条
[91]   NITRIC-OXIDE AND THE CONTROL OF RENIN SECRETION [J].
REID, IA ;
CHIU, YJ .
FUNDAMENTAL & CLINICAL PHARMACOLOGY, 1995, 9 (04) :309-323
[92]   Therapeutic Implications for PDE2 and cGMP/cAMP Mediated Crosstalk in Cardiovascular Diseases [J].
Sadek, Mirna S. ;
Cachorro, Eleder ;
El-Armouche, Ali ;
Kaemmerer, Susanne .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (20) :1-30
[93]   Effects of nitric oxide on aldosterone synthesis and nitric oxide synthase activity in glomerulosa cells from bovine adrenal gland [J].
Sainz, JM ;
Reche, C ;
Rábano, MA ;
Mondillo, C ;
Patrignan, ZJ ;
Macarulla, JM ;
Pignataro, OP ;
Trueba, M .
ENDOCRINE, 2004, 24 (01) :61-71
[94]   Neuronal Nitric Oxide Synthase Supports Renin Release During Sodium Restriction Through Inhibition of Phosphodiesterase 3 [J].
Sallstrom, Johan ;
Jensen, Boye L. ;
Skott, Ole ;
Gao, Xiang ;
Persson, A. Erik G. .
AMERICAN JOURNAL OF HYPERTENSION, 2010, 23 (11) :1241-1246
[95]   Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas [J].
Santos, RAS ;
Silva, ACSE ;
Maric, C ;
Silva, DMR ;
Machado, RP ;
de Buhr, I ;
Heringer-Walther, S ;
Pinheiro, SVB ;
Lopes, MT ;
Bader, M ;
Mendes, EP ;
Lemos, VS ;
Campagnole-Santos, MJ ;
Schultheiss, HP ;
Speth, R ;
Walther, T .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (14) :8258-8263
[96]   Nitric oxide synthase and cGMP-mediated stimulation of renin secretion [J].
Sayago, CM ;
Beierwaltes, WH .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2001, 281 (04) :R1146-R1151
[97]   Protein Kinase G Is Involved in Acute but Not in Long-Term Regulation of Renin Secretion [J].
Schramm, Andrea ;
Schweda, Frank ;
Sequeira-Lopez, Maria Luisa S. ;
Hofmann, Franz ;
Sandner, Peter ;
Schlossmann, Jens .
FRONTIERS IN PHARMACOLOGY, 2019, 10
[98]  
Scott JD, 2000, ADV PHARMACOL, V47, P175
[99]   Hemodynamic, Hormonal, and Renal Actions of Phosphodiesterase-9 Inhibition in Experimental Heart Failure [J].
Scott, Nicola J. A. ;
Rademaker, Miriam T. ;
Charles, Christopher J. ;
Espiner, Eric A. ;
Richards, A. Mark .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2019, 74 (07) :889-901
[100]   Current knowledge on the acute regulation of steroidogenesis [J].
Selvaraj, Vimal ;
Stocco, Douglas M. ;
Clark, Barbara J. .
BIOLOGY OF REPRODUCTION, 2018, 99 (01) :13-26
45678910111213