Regulation of the renin-angiotensin-aldosterone system by cyclic nucleotides and phosphodiesterases

被引：4

作者：

Gambaryan, Stepan ^{[1
]}

Mohagaonkar, Sanika ^{[2
,3
]}

Nikolaev, Viacheslav O. ^{[2
,3
]}

机构：

[1] Russian Acad Sci, Sechenov Inst Evolutionary Physiol & Biochem, St Petersburg, Russia

[2] Univ Med Ctr Hamburg Eppendorf, Inst Expt Cardiovasc Res, Hamburg, Germany

[3] German Ctr Cardiovasc Res DZHK, Partner Site Hamburg Kiel Lubeck, Hamburg, Germany

来源：

FRONTIERS IN ENDOCRINOLOGY | 2023年 / 14卷

关键词：

cAMP; cGMP; phosphodiesterase; renin; aldosterone; NITRIC-OXIDE SYNTHASE; ADRENAL GLOMERULOSA CELLS; ATRIAL-NATRIURETIC-FACTOR; DEPENDENT PROTEIN-KINASE; ZONA GLOMERULOSA; GENE-TRANSCRIPTION; JUXTAGLOMERULAR CELLS; ADENYLATE-CYCLASE; HUMAN PLATELETS; MESSENGER-RNA;

D O I：

10.3389/fendo.2023.1239492

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The renin-angiotensin-aldosterone system (RAAS) is one of the key players in the regulation of blood volume and blood pressure. Dysfunction of this system is connected with cardiovascular and renal diseases. Regulation of RAAS is under the control of multiple intracellular mechanisms. Cyclic nucleotides and phosphodiesterases are the major regulators of this system since they control expression and activity of renin and aldosterone. In this review, we summarize known mechanisms by which cyclic nucleotides and phosphodiesterases regulate renin gene expression, secretion of renin granules from juxtaglomerular cells and aldosterone production from zona glomerulosa cells of adrenal gland. We also discuss several open questions which deserve future attention.

引用

页数：11

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