As inclusions are inevitable from the material-producing processes, an engineering concept regarding multiple features of them is needed for material design. In this study, a unique approach integrating physical-meaningful microstructure-sensitive models with the machine-learning-based data-driven model is proposed to reveal the complex relationship between the fatigue life of materials with intrinsic features of inclusions including size, stiffness, thermal properties, and extrinsic stress amplitudes. This high-fidelity presentation of the relation of these variables enables a detailed and systematic analysis of the effects of inclusions on fatigue life. The data-based phase map provides a designing envelope of inclusion features for fatigue-resistant steels.