Lipid droplet biogenesis and functions in health and disease

被引：297

作者：

Zadoorian, Armella ^{[1
]}

Du, Ximing ^{[1
]}

Yang, Hongyuan ^{[1
]}

机构：

[1] Univ New South Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW, Australia

来源：

NATURE REVIEWS ENDOCRINOLOGY | 2023年 / 19卷 / 08期

基金：

澳大利亚研究理事会; 澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;

关键词：

FATTY LIVER-DISEASE; COA-CHOLESTEROL ACYLTRANSFERASE; CIDEA GENE V115F; DIACYLGLYCEROL ACYLTRANSFERASE; ENDOPLASMIC-RETICULUM; INSULIN-RESISTANCE; ALPHA-SYNUCLEIN; CELL-DEATH; CONFERS SUSCEPTIBILITY; MITOCHONDRIAL-FUNCTION;

D O I：

10.1038/s41574-023-00845-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This Review outlines our current understanding of the biogenesis and functions of lipid droplets in health and disease, highlighting a key role for lipid droplet biogenesis in alleviating cellular stress. Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being recognized for their versatility beyond energy storage. Advances uncovering the intricacies of their biogenesis and the diversity of their physiological and pathological roles have yielded new insights into lipid droplet biology. Despite these insights, the mechanisms governing the biogenesis and functions of lipid droplets remain incompletely understood. Moreover, the causal relationship between the biogenesis and function of lipid droplets and human diseases is poorly resolved. Here, we provide an update on the current understanding of the biogenesis and functions of lipid droplets in health and disease, highlighting a key role for lipid droplet biogenesis in alleviating cellular stresses. We also discuss therapeutic strategies of targeting lipid droplet biogenesis, growth or degradation that could be applied in the future to common diseases, such as cancer, hepatic steatosis and viral infection.

引用

页码：443 / 459

页数：17

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