A Low-Cost Handheld Reconfigurable Impedimetric Readout System for Diagnostics of Viral Infections

被引：3

作者：

Tabrizi, Hamed Osouli ^{[1
]}

Salahandish, Razieh ^{[2
]}

Jalali, Pezhman ^{[3
]}

Khalghollah, Mahmood ^{[4
,5
]}

Haghayegh, Fatemeh ^{[3
]}

Sanati-Nezhad, Amir ^{[6
]}

Ghafar-Zadeh, Ebrahim ^{[1
]}

机构：

[1] York Univ, Lassonde Sch Engn, Dept Elect Engn & Comp Sci, Biolog Inspired Sensors & Actuators, Toronto, ON M3J 1P3, Canada

[2] York Univ, Lassonde Sch Engn, Dept Elect Engn & Comp Sci, Labs Adv Technol Hlth Assessment, Toronto, ON M3J 1P3, Canada

[3] Univ Calgary, Dept Mech & Mfg Engn, BioMEMS & Bioinspired Microfluid Lab, Calgary, AB T2N 1N4, Canada

[4] Univ Calgary, Dept Elect & Software Engn, Calgary, AB T2N 1N4, Canada

[5] Univ Calgary, Dept Mech & Mfg Engn, BioMEMS & Bioinspired Microfluid Lab, Calgary, AB T2N 1N4, Canada

[6] Univ Calgary, Biomed Engn Grad Program, Calgary, AB T2N 1N4, Canada

来源：

IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT | 2023年 / 72卷

基金：

加拿大健康研究院;

关键词：

Sensors; Electrodes; Impedance; COVID-19; Integrated circuits; Antibodies; Impedance measurement; Biosensor; electronic readout system; impedance measurement; SARS-CoV-2;

D O I：

10.1109/TIM.2023.3265117

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

This article presents a portable impedimetric biosensor for detecting infectious diseases, such as SARS-CoV-2 infections. A bio-ready sensing electrode functionalized with SARS-CoV-2 nucleocapsid antibody was employed to quantitatively convert the concentration of nucleocapsid protein (N-protein) into impedance changes. In this article, we proposed a readout system with a dynamic input range of 200-O-1-MO magnitude and 0(?)-180(?) phase. The resolution of this device is 1% and 6.5(?) for measuring the magnitude and phase, respectively. Herein, we demonstrate and discuss the proposed system's functionality, sensitivity, and selectivity using the clinical swab samples. As per these results, this readout system is suitable for the detection of N-protein ranging up to 10 000 pg/mL with a resolution of 56 fg/mL. The proposed impedimetric sensing system can be adopted for the detection of infectious diseases in the future. This low-cost (<$80) device using off-the-shelf is a unique candidate for batch production purposes during urgent pandemic situations.

引用

页数：8

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