A Duration-Dependent Interaction Between High-Intensity Light and Unrestricted Vision in the Drive for Myopia Control

被引：15

作者：

Biswas, Sayantan ^{[1
]}

Muralidharan, Arumugam R. ^{[1
,2
]}

Betzler, Bjorn Kaijun ^{[3
]}

Busoy, Joanna Marie Fianza ^{[1
]}

Barathi, Veluchamy A. ^{[1
,3
]}

Tan, Royston K. Y. ^{[1
,2
]}

Low, Wan Yu Shermaine ^{[1
]}

Milea, Dan ^{[1
,2
,4
]}

Kathrani, Biten K. ^{[5
]}

Brennan, Noel A. ^{[5
]}

Najjar, Raymond P. ^{[1
,2
,6
,7
,8
]}

机构：

[1] Singapore Eye Res Inst, Singapore, Singapore

[2] Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program, Singapore, Singapore

[3] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore

[4] Singapore Natl Eye Ctr, Singapore, Singapore

[5] Johnson & Johnson Vis Care, Jacksonville, FL USA

[6] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Eye N Brain Res Grp, Singapore, Singapore

[7] Natl Univ Singapore, Ctr Innovat & Precis Eye Hlth, Yong Loo Lin Sch Med, Singapore, Singapore

[8] Natl Univ Singapore, Singapore Eye Res Inst, Yong Loo Lin Sch Med, Dept Ophthalmol,Academia, 20 Coll Rd,Discovery Tower Level 6, Singapore 169856, Singapore

来源：

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | 2023年 / 64卷 / 03期

关键词：

myopia; animal model; unrestricted vision; optical defocus; high-intensity light; axial length; choroid; outdoor time; LENS-INDUCED MYOPIA; FORM-DEPRIVATION MYOPIA; CHOROIDAL BLOOD-FLOW; HYPEROPIC DEFOCUS; EYE GROWTH; REFRACTIVE DEVELOPMENT; AMBIENT ILLUMINANCE; DOPAMINE RELEASE; RETINAL DOPAMINE; OCULAR GROWTH;

D O I：

10.1167/iovs.64.3.31

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

PURPOSE. To evaluate the duration-dependent and synergetic impact of high-intensity light (HL) and unrestricted vision (UnV) on lens-induced myopia (LIM) development in chickens.METHODS. Myopia was induced in one eye in chicks (10 groups, n = 126) from day 1 posthatching (D1) until day 8 (D8) using -10 diopter (D) lenses. Fellow eyes remained uncovered as controls. Nine groups were exposed daily to 2, 4, or 6 hours of HL (15,000 lux), UnV (removal of -10 D lens), or both (HL + UnV). One group served as the LIM group without any interventions. Ocular axial length (AL), refractive error, and choroidal thickness were measured on D1, D4, and D8. Outcome measures are expressed as inte-rocular difference (IOD = experimental eye - control eye) +/- SEM.RESULTS. By D8, LIM increased AL (0.36 +/- 0.04 mm), myopic refraction (-9.02 +/- 0.37 D), and choroidal thinning (-90.27 +/- 16.44 mu m) in the LIM group (all, P < 0.001). Compared to the LIM group, exposure to 2, 4, or 6 hours of HL, UnV, or HL + UnV reduced myopic refraction in a duration-dependent manner, with UnV being more effective than HL (P < 0.05). Only 6 hours of HL + UnV (not 2 or 4 hours) prevented LIM and was more effective than UnV (P = 0.004) or HL (P < 0.001) in reducing myopic refraction and more effective than HL (P < 0.001) in reducing axial elongation.CONCLUSIONS. Daily exposure to 2, 4, or 6 hours of HL, UnV, or HL + UnV reduced lens -induced myopic refraction in a duration-dependent manner in chickens. Only 6 hours of HL + UnV completely stopped LIM development. The synergetic effect of HL and UnV is dependent on the duration of the interventions.

引用

页数：10

共 64 条

[61] Comparison of form-deprived myopia and lens-induced myopia in guinea pigs [J].