Polygenic Risk Scores for Alzheimer's Disease and General Cognitive Function Are Associated With Measures of Cognition in Older South Asians

被引：5

作者：

Zhao, Wei ^{[1
,2
]}

Smith, Jennifer A. ^{[1
,2
,10
]}

Wang, Yi Zhe ^{[1
]}

Chintalapati, Manjusha ^{[3
,4
]}

Ammous, Farah ^{[1
]}

Yu, Miao ^{[1
]}

Moorjani, Priya ^{[3
,4
]}

Ganna, Andrea ^{[5
]}

Gross, Alden ^{[6
]}

Dey, Sharmistha ^{[7
]}

Benerjee, Joyita ^{[8
]}

Chatterjee, Prasun ^{[8
]}

Dey, Aparajit B. ^{[8
]}

Lee, Jinkook ^{[9
]}

Kardia, Sharon L. R. ^{[1
]}

机构：

[1] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI USA

[2] Univ Michigan, Inst Social Res, Survey Res Ctr, Ann Arbor, MI USA

[3] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA USA

[4] Univ Calif Berkeley, Ctr Computat Biol, Berkeley, CA USA

[5] Inst Mol Med Finland, Helsinki, Finland

[6] Johns Hopkins Univ, Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA

[7] All India Inst Med Sci, Dept Biophys, New Delhi, India

[8] All India Inst Med Sci, Dept Geriatr Med, New Delhi, India

[9] Univ Southern Calif, Dept Econ, Los Angeles, CA USA

[10] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, 1415 Washington Hts,2631, Ann Arbor, MI 48109 USA

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2023年 / 78卷 / 05期

关键词：

Dementia; Genetic risk score; India; Population structure; Single-nucleotide polymorphism; INDIA-DIAGNOSTIC ASSESSMENT; GENOME-WIDE ASSOCIATION; APOLIPOPROTEIN-E; SOCIOECONOMIC-STATUS; POPULATION; LOCI; METAANALYSIS; DEMENTIA; PERFORMANCE; INEQUALITY;

D O I：

10.1093/gerona/glad057

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Genome-wide association studies (GWAS) conducted in European ancestry (EA) have identified hundreds of single-nucleotide polymorphisms (SNPs) associated with general cognitive function and/or Alzheimer's disease (AD). The association between these SNPs and cognitive function has not been fully evaluated in populations with complex genetic substructure such as South Asians. This study investigated whether SNPs identified in EA GWAS, either individually or as polygenic risk scores (PRSs), were associated with general cognitive function and 5 broad cognitive domains in 932 South Asians from the Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD). We found that SNPs identified from AD GWAS were more strongly associated with cognitive function in LASI-DAD than those from a GWAS of general cognitive function. PRSs for general cognitive function and AD explained up to 1.1% of the variability in LASI-DAD cognitive domain scores. Our study represents an important stepping stone toward better characterization of the genetic architecture of cognitive aging in the Indian/South Asian population and highlights the need for further research that may lead to the identification of new variants unique to this population.

引用

页码：743 / 752

页数：10

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