Mechanisms of esophageal stricture after extensive endoscopic resection: a transcriptomic analysis

被引：1

作者：

Barret, Maximilien ^{[1
,2
,3
,10
]}

Doridot, Ludivine ^{[2
,3
,4
]}

Le Gall, Morgane ^{[5
]}

Beuvon, Frederic ^{[6
,7
]}

Jacques, Sebastien ^{[2
,6
]}

Pellat, Anna ^{[1
,2
]}

Belle, Arthur ^{[1
]}

Abou Ali, Einas ^{[1
]}

Dhooge, Marion ^{[1
]}

Leblanc, Sarah ^{[1
,8
]}

Camus, Marine ^{[1
,9
]}

Nicco, Carole ^{[2
,3
]}

Coriat, Romain ^{[1
,2
,3
]}

Chaussade, Stanislas ^{[1
,2
]}

Batteux, Frederic ^{[2
,3
,4
]}

Prat, Frederic ^{[1
,2
,3
]}

机构：

[1] Cochin Hosp, Assistance Publ Hop Paris, Dept Gastroenterol & Digest Oncol, Paris, France

[2] Univ Paris, Paris, France

[3] Inst Cochin, INSERM U1016, Paris, France

[4] Cochin Hosp, Assistance Publ Hop Paris, Dept Immunol, Paris, France

[5] Univ Paris, Inst Cochin, INSERM, CNRS,3P5 Prote facil, F-75014 Paris, France

[6] CNRS UMR8104, Genom, Paris, France

[7] Cochin Hosp, Assistance Publ Hop Paris, Dept Pathol, Paris, France

[8] Jean Mermoz Private Hosp, Dept Gastroenterol, Lyon, France

[9] St Antoine Hosp, Assistance Publ Hop Paris, Dept Gastroenterol, Paris, France

[10] Hop Cochin, Serv Gastroenterol & Oncol Digest, 27 Rue Faubourg St Jacques, F-75014 Paris, France

来源：

ENDOSCOPY INTERNATIONAL OPEN | 2023年 / 11卷 / 02期

关键词：

SUBMUCOSAL DISSECTION; MUCOSAL RESECTION; INTERFERON-GAMMA; PREVENTION; STENOSIS; INJECTION; EFFICACY; CELLS;

D O I：

10.1055/a-2000-8801

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background and study aims Esophageal stricture is the most frequent adverse event after endoscopic resection for early esophageal neoplasia. Currently available treatments for the prevention of esophageal stricture are poorly effective and associated with major adverse events. Our aim was to identify transcripts specifically overexpressed or repressed in patients who have developed a post-endoscopic esophageal stricture, as potential targets for stricture prevention.Patients and methods We conducted a prospective single-center study in a tertiary endoscopy center. Patients scheduled for an endoscopic resection and considered at risk of esophageal stricture were offered inclusion in the study. The healthy mucosa and resection bed were biopsied on Days 0, 14, and 90. A transcriptomic analysis by microarray was performed, and the differences in transcriptomic profile compared between patients with and without esophageal strictures.Results Eight patients, four with esophageal stricture and four without, were analyzed. The mean +/- SD circumferential extension of the mucosal defect was 85 +/- 11 %. The transcriptomic analysis in the resection bed at day 14 found an activation of the interleukin (IL)-1 group (Z score = 2.159, P = 0.0137), while interferon-gamma (INF gamma) and NUPR1 were inhibited (Z score = -2.375, P = 0.0022 and Z score = -2.333, P = 0.00131) in the stricture group. None of the activated or inhibited transcripts were still significantly so in any of the groups on Day 90.Conclusions Our data suggest that IL-1 inhibition or INF gamma supplementation could constitute promising targets for post-endoscopic esophageal stricture prevention.

引用

页码：E149 / E156

页数：8

共 37 条

[1] Management of esophageal strictures after endoscopic resection for early neoplasia [J].