Microglia in Microbiota-Gut-Brain Axis: A Hub in Epilepsy

被引：9

作者：

Liu, Yuyang ^{[1
,2
,3
]}

Jia, Ningkang ^{[1
,3
,4
]}

Tang, Chuqi ^{[1
,2
,3
]}

Long, Hao ^{[1
,2
]}

Wang, Jun ^{[1
,2
,3
]}

机构：

[1] Southern Med Univ, Nanfang Hosp, Dept Neurosurg, Guangzhou 510515, Peoples R China

[2] Southern Med Univ, Clin Med Coll 1, Guangzhou, Peoples R China

[3] Southern Med Univ, Neural Networks Surg Team, Guangzhou, Peoples R China

[4] Southern Med Univ, Clin Med Coll 2, Guangzhou, Peoples R China

来源：

MOLECULAR NEUROBIOLOGY | 2024年 / 61卷 / 09期

关键词：

Drug-resistant epilepsy; Vagus nerve; Microbiome; Gut-brain axis; Microglia; DRUG-RESISTANT EPILEPSY; VAGUS NERVE-STIMULATION; TRYPTOPHAN-METABOLISM; LONG-TERM; ACTIVATION; MODULATION; SYSTEM; INFLAMMATION; DISEASE; IMMUNE;

D O I：

10.1007/s12035-024-04022-w

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

There is growing concern about the role of the microbiota-gut-brain axis in neurological illnesses, and it makes sense to consider microglia as a critical component of this axis in the context of epilepsy. Microglia, which reside in the central nervous system, are dynamic guardians that monitor brain homeostasis. Microglia receive information from the gut microbiota and function as hubs that may be involved in triggering epileptic seizures. Vagus nerve bridges the communication in the axis. Essential axis signaling molecules, such as gamma-aminobutyric acid, 5-hydroxytryptamin, and short-chain fatty acids, are currently under investigation for their participation in drug-resistant epilepsy (DRE). In this review, we explain how vagus nerve connects the gut microbiota to microglia in the brain and discuss the emerging concepts derived from this interaction. Understanding microbiota-gut-brain axis in epilepsy brings hope for DRE therapies. Future treatments can focus on the modulatory effect of the axis and target microglia in solving DRE.

引用

页码：7109 / 7126

页数：18

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