Network pharmacology prediction and molecular docking-based strategy to explore the potential mechanism of Radix Astragali against hypopharyngeal carcinoma

被引：0
作者：
Zhang, Jianing [1 ]
Li, Lianhe [1 ]
机构：
[1] Cent Hosp Chaoyang, Dept Otorhinolaryngol Head & Neck Surg, Chaoyang 122000, Liaoning, Peoples R China
来源：
SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期
关键词：
GASTRIC-CANCER CELLS; TNF-ALPHA; EXPRESSION; QUERCETIN; PATHWAY; PROLIFERATION; APOPTOSIS; MIGRATION; SAFETY;
D O I：
10.1038/s41598-023-50605-3
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
To explore the anti-tumor effects of Radix Astragali on hypopharyngeal carcinoma and its mechanism. We have bioinformatically analyzed the potential targets of Radix Astragali and predicted the molecular mechanism of Radix Astragali treating of hypopharyngeal carcinoma. The binding process of the hub targets that could prolong the survival time of hypopharyngeal cancer patients with Radix Astragali was simulated by molecular docking. The results showed that 17 out of 36 hub targets could effectively improve the 5-year survival rate of hypopharyngeal cancer patients. Radix Astragali acts on hypopharyngeal carcinoma by regulating a signaling network formed by hub targets connecting multiple signaling pathways and is expected to become a drug for treating and prolonging hypopharyngeal carcinoma patients' survival time.
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页数：17
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