Omega-3 PUFAs prevent bone impairment and bone marrow adiposity in mouse model of obesity

被引：12

作者：

Benova, Andrea ^{[1
,2
]}

Ferencakova, Michaela ^{[1
]}

Bardova, Kristina ^{[3
]}

Funda, Jiri ^{[3
]}

Prochazka, Jan ^{[4
]}

Spoutil, Frantisek ^{[4
]}

Cajka, Tomas ^{[5
]}

Dzubanova, Martina ^{[1
,2
]}

Balcaen, Tim ^{[6
,7
,8
]}

Kerckhofs, Greet ^{[6
,7
,9
,10
]}

Willekens, Wouter ^{[11
]}

van Lenthe, G. Harry ^{[12
]}

Charyyeva, Arzuv ^{[1
]}

Alquicer, Glenda ^{[1
]}

Pecinova, Alena ^{[13
]}

Mracek, Tomas ^{[13
]}

Horakova, Olga ^{[3
]}

Coupeau, Roman ^{[1
]}

Hansen, Morten Svarer ^{[14
]}

Rossmeisl, Martin ^{[3
]}

Kopecky, Jan ^{[3
]}

Tencerova, Michaela ^{[1
]}

机构：

[1] Czech Acad Sci, Lab Mol Physiol Bone, Inst Physiol, Prague, Czech Republic

[2] Charles Univ Prague, Fac Sci, Prague, Czech Republic

[3] Czech Acad Sci, Inst Physiol, Lab Adipose Tissue Biol, Prague, Czech Republic

[4] Czech Acad Sci, Inst Mol Genet, Czech Ctr Phenogen & Lab Transgenic Models Dis, Prague, Czech Republic

[5] Czech Acad Sci, Lab Translat Metab, Inst Physiol, Prague, Czech Republic

[6] UCLouvain, Inst Mech Mat & Civil Engn, Biomech Lab, Louvain la Neuve, Belgium

[7] UCLouvain, Inst Expt & Clin Res, Pole Morphol, Brussels, Belgium

[8] Katholieke Univ Leuven, Dept Chem Mol Design & Synth, Leuven, Belgium

[9] Katholieke Univ Leuven, Dept Mat Engn, Leuven, Belgium

[10] Katholieke Univ Leuven, Div Skeletal Tissue Engn, Prometheus, Leuven, Belgium

[11] Katholieke Univ Leuven, FIBEr, Leuven, Belgium

[12] Katholieke Univ Leuven, Dept Mech Engn, Leuven, Belgium

[13] Czech Acad Sci, Lab Bioenerget, Inst Physiol, Prague, Czech Republic

[14] Odense Univ Hosp, Dept Endocrinol, Mol Endocrinol Lab KMEB, DK-5000 Odense C, Denmark

来源：

COMMUNICATIONS BIOLOGY | 2023年 / 6卷 / 01期

关键词：

N-3; FATTY-ACIDS; DIET-INDUCED OBESITY; STEM-CELLS; TISSUE; MICE; MASS; CONTRIBUTES; OSTEOCLASTS; TOMOGRAPHY; INHIBITION;

D O I：

10.1038/s42003-023-05407-8

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Obesity adversely affects bone and fat metabolism in mice and humans. Omega-3 polyunsaturated fatty acids (omega-3 PUFAs) have been shown to improve glucose metabolism and bone homeostasis in obesity. However, the impact of omega-3 PUFAs on bone marrow adipose tissue (BMAT) and bone marrow stromal cell (BMSC) metabolism has not been intensively studied yet. In the present study we demonstrated that omega-3 PUFA supplementation in high fat diet (HFD + F) improved bone parameters, mechanical properties along with decreased BMAT in obese mice when compared to the HFD group. Primary BMSCs isolated from HFD + F mice showed decreased adipocyte and higher osteoblast differentiation with lower senescent phenotype along with decreased osteoclast formation suggesting improved bone marrow microenvironment promoting bone formation in mice. Thus, our study highlights the beneficial effects of omega-3 PUFA-enriched diet on bone and cellular metabolism and its potential use in the treatment of metabolic bone diseases.

引用

页数：17

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