Comprehensive elucidation of resting-state functional connectivity in anorexia nervosa by a multicenter cross-sectional study

被引：5

作者：

Sudo, Yusuke ^{[1
,2
,3
]}

Ota, Junko ^{[1
,4
,5
,6
]}

Takamura, Tsunehiko ^{[7
]}

Kamashita, Rio ^{[1
,5
,6
]}

Hamatani, Sayo ^{[1
,5
,6
,8
]}

Numata, Noriko ^{[1
,5
,6
]}

Chhatkuli, Ritu Bhusal ^{[1
,4
,5
,6
]}

Yoshida, Tokiko ^{[1
]}

Takahashi, Jumpei ^{[9
]}

Kitagawa, Hitomi ^{[1
]}

Matsumoto, Koji ^{[10
]}

Masuda, Yoshitada ^{[10
]}

Nakazato, Michiko ^{[11
]}

Sato, Yasuhiro ^{[12
]}

Hamamoto, Yumi ^{[13
,14
]}

Shoji, Tomotaka ^{[12
,15
,16
]}

Muratsubaki, Tomohiko ^{[17
]}

Sugiura, Motoaki ^{[14
,18
]}

Fukudo, Shin ^{[12
,17
]}

Kawabata, Michiko ^{[19
]}

Sunada, Momo ^{[19
]}

Noda, Tomomi ^{[19
]}

Tose, Keima ^{[19
]}

Isobe, Masanori ^{[19
]}

Kodama, Naoki ^{[20
]}

Kakeda, Shingo ^{[21
]}

Takahashi, Masatoshi ^{[20
]}

Takakura, Shu ^{[22
]}

Gondo, Motoharu ^{[22
]}

Yoshihara, Kazufumi ^{[22
]}

Moriguchi, Yoshiya ^{[7
,23
]}

Shimizu, Eiji ^{[1
,2
,5
,6
]}

Sekiguchi, Atsushi ^{[7
,24
,25
]}

Hirano, Yoshiyuki ^{[1
,4
,5
,6
]}

机构：

[1] Chiba Univ, Res Ctr Child Mental Dev, Chiba, Japan

[2] Chiba Univ, Dept Cognit Behav Physiol, Chiba, Japan

[3] Chiba Univ Hosp, Dept Psychiat, Chiba, Japan

[4] Natl Inst Quantum Sci & Technol, Inst Quantum Med Sci, Dept Mol Imaging & Theranost, Appl MRI Res, Chiba, Japan

[5] Chiba Univ, Hamamatsu Univ, Osaka Univ, Kanazawa Univ,Sch Med,United Grad Sch Child Dev, Suita, Japan

[6] Univ Fukui, Suita, Japan

[7] Natl Inst Mental Hlth, Natl Ctr Neurol & Psychiat, Dept Behav Med, Kodaira, Japan

[8] Univ Fukui, Res Ctr Child Mental Dev, Eiheizi, Japan

[9] Chiba Aoba Municipal Hosp, Dept Psychiat, Chiba, Japan

[10] Chiba Univ Hosp, Dept Radiol, Chiba, Japan

[11] Int Univ Hlth & Welf, Sch Med, Dept Psychiat, Narita, Japan

[12] Tohoku Univ Hosp, Dept Psychosomat Med, Sendai, Japan

[13] Northumbria Univ, Dept Psychol, Newcastle Upon Tyne, England

[14] Tohoku Univ, Inst Dev Aging & Canc, Dept Human Brain Sci, Sendai, Japan

[15] Nagamachi Hosp, Dept Internal Med, Sendai, Japan

[16] Tohoku Univ, Dept Psychosomat Med, Sch Med, Sendai, Japan

[17] Tohoku Univ, Dept Psychosomat Med, Grad Sch Med, Sendai, Japan

[18] Tohoku Univ, Int Res Inst Disaster Sci, Cognit Sci Lab, Sendai, Japan

[19] Kyoto Univ, Dept Psychiat, Grad Sch Med, Kyoto, Japan

[20] Univ Occupat & Environm Hlth, Dept Neurol, Div Psychosomat Med, Kitakyushu, Japan

[21] Hirosaki Univ, Dept Radiol, Grad Sch Med, Hirosaki, Japan

[22] Kyushu Univ Hosp, Dept Psychosomat Med, Fukuoka, Japan

[23] Natl Ctr Neurol & Psychiat, Dept Sleep Wake Disorders, Kodaira, Japan

[24] Natl Ctr Neurol & Psychiat, Ctr Eating Disorder Res & Informat, Kodaira, Japan

[25] Natl Ctr Neurol & Psychiat, Integrat Brain Imaging Ctr, Dept Adv Neuroimaging, Kodaira, Japan

来源：

PSYCHOLOGICAL MEDICINE | 2024年 / 54卷 / 10期

基金：

日本学术振兴会;

关键词：

eating disorder; anorexia nervosa; anorexia nervosa restricting type; anorexia nervosa binge/purge type; functional connectivity; resting-state fMRI; whole-brain analysis; dorsolateral prefrontal cortex (DLPFC); cerebellum; temporal lobe; diagnostic marker; EATING-DISORDERS; PREFRONTAL CORTEX; NETWORK; CEREBELLUM; EMOTION; WOMEN; ALEXITHYMIA; CONNECTOME; IMPAIRMENT; ACTIVATION;

D O I：

10.1017/S0033291724000485

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Background Previous research on the changes in resting-state functional connectivity (rsFC) in anorexia nervosa (AN) has been limited by an insufficient sample size, which reduced the reliability of the results and made it difficult to set the whole brain as regions of interest (ROIs). Methods We analyzed functional magnetic resonance imaging data from 114 female AN patients and 135 healthy controls (HC) and obtained self-reported psychological scales, including eating disorder examination questionnaire 6.0. One hundred sixty-four cortical, subcortical, cerebellar, and network parcellation regions were considered as ROIs. We calculated the ROI-to-ROI rsFCs and performed group comparisons. Results Compared to HC, AN patients showed 12 stronger rsFCs mainly in regions containing dorsolateral prefrontal cortex (DLPFC), and 33 weaker rsFCs primarily in regions containing cerebellum, within temporal lobe, between posterior fusiform cortex and lateral part of visual network, and between anterior cingulate cortex (ACC) and thalamus (p < 0.01, false discovery rate [FDR] correction). Comparisons between AN subtypes showed that there were stronger rsFCs between right lingual gyrus and right supracalcarine cortex and between left temporal occipital fusiform cortex and medial part of visual network in the restricting type compared to the binge/purging type (p < 0.01, FDR correction). Conclusion Stronger rsFCs in regions containing mainly DLPFC, and weaker rsFCs in regions containing primarily cerebellum, within temporal lobe, between posterior fusiform cortex and lateral part of visual network, and between ACC and thalamus, may represent categorical diagnostic markers discriminating AN patients from HC.

引用

页码：2347 / 2360

页数：14

共 81 条

[71] Structural and functional brain alterations in anorexia nervosa:A multimodal meta-analysis of neuroimaging studies [J].