Epigenetic aging of human blood cells is influenced by the age of the host body

被引：3

作者：

Holland, Petter ^{[1
]}

Istre, Mette ^{[1
]}

Ali, Maryan M. ^{[2
]}

Gedde-Dahl, Tobias ^{[3
]}

Buechner, Jochen ^{[4
]}

Wildhagen, Mari ^{[1
]}

Brunvoll, Sonja H. ^{[1
]}

Horvath, Steve ^{[5
]}

Matsuyama, Shigemi ^{[6
]}

Dahl, John Arne ^{[1
]}

Stoeltzel, Friedrich ^{[7
,8
]}

Soraas, Arne ^{[1
]}

机构：

[1] Oslo Univ Hosp, Dept Microbiol, Oslo, Norway

[2] Baerum Hosp, Dept Internal Med, Drammen, Norway

[3] Oslo Univ Hosp, Dept Hematol, Oslo, Norway

[4] Oslo Univ Hosp, Dept Pediat Hematol & Oncol, Oslo, Norway

[5] Altos Labs, Cambridge, England

[6] Case Western Reserve Univ, Dept Med, Dept Ophthalmol & Visual Sci, Cleveland, OH USA

[7] Univ Kiel, Univ Hosp Schleswig Holstein Kiel, Dept Internal Med 2, Div Stem Cell Transplantat & Cellular Therapies, Kiel, Germany

[8] TUD Dresden Univ Technol, Fac Med Carl Gustav Carus, Dresden, Germany

来源：

AGING CELL | 2024年 / 23卷 / 05期

关键词：

aging; epigenetic; hematopoietic; hsc; human; parabiosis; transplantation;

D O I：

10.1111/acel.14112

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Allogenic hematopoietic stem cell transplantation is a therapeutic procedure performed over a wide range of donor and recipient age combinations, representing natural experiments of how the age of the recipient affects aging in transplanted donor cells in vivo. We measured DNA methylation and epigenetic aging in donors and recipients and found that biological epigenetic clocks are accelerated in cells transplanted into an older body and decelerated in a younger body. This is the first evidence that the age of the circulating environment influences human epigenetic aging in vivo. Epigenetic aging is accellerated in cells living in an older body compared to cells living in a younger body.image

引用

页数：5

共 50 条

[41] Obesity accelerates epigenetic aging of human liver
Horvath, Steve
Erhart, Wiebke
Brosch, Mario
Ammerpohl, Ole
von Schoenfels, Witigo
Ahrens, Markus
Heits, Nils
Bell, Jordana T.
Tsai, Pei-Chien
Spector, Tim D.
Deloukas, Panos
Siebert, Reiner
Sipos, Bence
Becker, Thomas
Roecken, Christoph
Schafmayer, Clemens
Hampe, Jochen
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (43) : 15538 - 15543
[42] Epigenetic age is a cell-intrinsic property in transplanted human hematopoietic cells
Soraas, Arne
Matsuyama, Mieko
de Lima, Marcos
Wald, David
Buechner, Jochen
Gedde-Dahl, Tobias
Soraas, Camilla Lund
Chen, Brian
Ferrucci, Luigi
Dahl, John Arne
Horvath, Steve
Matsuyama, Shigemi
AGING CELL, 2019, 18 (02)
[43] Effect of age on human peripheral blood stem cells
Egusa, Y
Fujiwara, Y
Syahruddin, E
Isobe, T
Yamakido, M
ONCOLOGY REPORTS, 1998, 5 (02) : 397 - 400
[44] Profiling epigenetic age in single cells
Trapp, Alexandre
Kerepesi, Csaba
Gladyshev, Vadim N.
NATURE AGING, 2021, 1 (12): : 1189 - 1201
[45] PROFILING EPIGENETIC AGE IN SINGLE CELLS
Trapp, Alexandre
Kerepesi, Csaba
Gladyshev, Vadim
INNOVATION IN AGING, 2021, 5 : 673 - 673
[46] Energy absorption of human red blood cells and conductivity of the cytoplasm influenced by temperature
Sudsiri, Chadapust J.
Ritchie, Raymond J.
BIOPHYSICAL CHEMISTRY, 2021, 273
[47] Epigenetic Regulation of Skin Cells in Natural Aging and Premature Aging Diseases
Orioli, Donata
Dellambra, Elena
CELLS, 2018, 7 (12)
[48] BACTERIAL SPOT OF TOMATO AS INFLUENCED BY TEMPERATURE AND BY AGE AND NUTRITION OF THE HOST
NAYUDU, MV
WALKER, JC
PHYTOPATHOLOGY, 1960, 50 (05) : 360 - 364
[49] An integrated -omics analysis of the epigenetic landscape of gene expression in human blood cells
Elizabeth M. Kennedy
George N. Goehring
Michael H. Nichols
Chloe Robins
Divya Mehta
Torsten Klengel
Eleazar Eskin
Alicia K. Smith
Karen N. Conneely
BMC Genomics, 19
[50] An integrated -omics analysis of the epigenetic landscape of gene expression in human blood cells
Kennedy, Elizabeth M.
Goehring, George N.
Nichols, Michael H.
Robins, Chloe
Mehta, Divya
Klengel, Torsten
Eskin, Eleazar
Smith, Alicia K.
Conneely, Karen N.
BMC GENOMICS, 2018, 19

← 1 2 3 4 5 →