Epigenetic aging of human blood cells is influenced by the age of the host body

被引：3

作者：

Holland, Petter ^{[1
]}

Istre, Mette ^{[1
]}

Ali, Maryan M. ^{[2
]}

Gedde-Dahl, Tobias ^{[3
]}

Buechner, Jochen ^{[4
]}

Wildhagen, Mari ^{[1
]}

Brunvoll, Sonja H. ^{[1
]}

Horvath, Steve ^{[5
]}

Matsuyama, Shigemi ^{[6
]}

Dahl, John Arne ^{[1
]}

Stoeltzel, Friedrich ^{[7
,8
]}

Soraas, Arne ^{[1
]}

机构：

[1] Oslo Univ Hosp, Dept Microbiol, Oslo, Norway

[2] Baerum Hosp, Dept Internal Med, Drammen, Norway

[3] Oslo Univ Hosp, Dept Hematol, Oslo, Norway

[4] Oslo Univ Hosp, Dept Pediat Hematol & Oncol, Oslo, Norway

[5] Altos Labs, Cambridge, England

[6] Case Western Reserve Univ, Dept Med, Dept Ophthalmol & Visual Sci, Cleveland, OH USA

[7] Univ Kiel, Univ Hosp Schleswig Holstein Kiel, Dept Internal Med 2, Div Stem Cell Transplantat & Cellular Therapies, Kiel, Germany

[8] TUD Dresden Univ Technol, Fac Med Carl Gustav Carus, Dresden, Germany

来源：

AGING CELL | 2024年 / 23卷 / 05期

关键词：

aging; epigenetic; hematopoietic; hsc; human; parabiosis; transplantation;

D O I：

10.1111/acel.14112

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Allogenic hematopoietic stem cell transplantation is a therapeutic procedure performed over a wide range of donor and recipient age combinations, representing natural experiments of how the age of the recipient affects aging in transplanted donor cells in vivo. We measured DNA methylation and epigenetic aging in donors and recipients and found that biological epigenetic clocks are accelerated in cells transplanted into an older body and decelerated in a younger body. This is the first evidence that the age of the circulating environment influences human epigenetic aging in vivo. Epigenetic aging is accellerated in cells living in an older body compared to cells living in a younger body.image

引用

页数：5

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