Predictors of mortality for perforated peptic ulcer disease in Malawi

被引：1

作者：

An, Selena J. ^{[1
]}

Davis, Dylane ^{[2
]}

Kayange, Linda ^{[3
]}

Gallaher, Jared ^{[1
]}

Charles, Anthony ^{[1
,3
,4
]}

机构：

[1] Univ N Carolina, Dept Surg, 4001 Burnett Womack Bldg,CB 7050, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Sch Med, 1001 Bondurant Hall,CB 9535, Chapel Hill, NC 27599 USA

[3] Kamuzu Cent Hosp, Dept Surg, Private Bag 149, Lilongwe, Malawi

[4] UNC Sch Med, Dept Surg, 4008 Burnett Womack Bldg,CB 7228, Chapel Hill, NC 27599 USA

来源：

AMERICAN JOURNAL OF SURGERY | 2023年 / 225卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Peptic ulcer disease; Perforation; Surgery; Malawi; SURGERY; RISK;

D O I：

10.1016/j.amjsurg.2022.11.029

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background: Mortality from perforated peptic ulcer disease (PUD) remains high, especially in sub-Saharan Africa. We sought to identify predictors of mortality following surgery for perforated PUD. Methods: We performed a retrospective study of acute care surgeries at Kamuzu Central Hospital (KCH) in Malawi from 2013 to 2022. Patients undergoing omental patch surgeries were included. Bivariate and multivariate analyses were used to model predictors of mortality. Results: A total of 248 patients were included. The mean age was 30 +/- 15 years. Ninety percent were male. Mortality rate was 22.2%. Predictors of mortality included age (adjusted odds ratio [AOR] 1.06, 95% confidence interval [CI] 1.03-1.09), shock index (AOR 1.86, 95% CI 1.14-3.03), days to operative intervention (AOR 1.44, 95% CI 1.10-1.88), and presence of complications (AOR 9.65, 95% CI 3.79-24.6). Conclusions: Mortality following surgery for perforated PUD remains high in this low-resource environment. In -hospital delay is a significant and modifiable predictor of mortality.

引用

页码：1081 / 1085

页数：5

共 30 条

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