Primary gastric amyloidosis associated with linitis plastica and delayed progression to systemic amyloidosis and multiple myeloma

被引：0

作者：

Khalil, Georges ^{[1
]}

Fiani, Dimitri ^{[2
]}

Antaki, Fares ^{[3
]}

Diab, Ernest ^{[4
]}

机构：

[1] Lebanese Amer Univ, St John Hosp, Gilbert & Rose Marie Chagoury Sch Med, Dept Internal Med, Beirut, Lebanon

[2] Univ St Joseph, Fac Med, Dept Internal Med, Beirut, Lebanon

[3] Univ Montreal, Ctr Hosp Univ, Ophthalmol, Montreal, PQ, Canada

[4] Univ St Joseph, Fac Med, Dept Hematol Oncol, Beirut, Lebanon

来源：

BMJ CASE REPORTS | 2023年 / 16卷 / 05期

关键词：

Cancer; see Oncology; Gastric cancer; Pathology; AL AMYLOIDOSIS; TUMOR;

D O I：

10.1136/bcr-2022-252786

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report the case of a woman in her 50s who underwent, 5 years prior, a total gastrectomy after neoadjuvant chemotherapy for diffuse-type gastric cancer diagnosed during a workup for isolated gastric primary light chain (AL) amyloidosis. At the time of diagnosis, immunoglobulins light chain measurements and bone marrow biopsy were performed to rule out multiple myeloma and came back normal. Three years later, the patient developed systemic amyloidosis involving the heart and the lungs, after which she developed multiple myeloma. Isolated amyloid deposits in the stomach are a rare finding. While AL amyloidosis is frequently found in concomitance with multiple myeloma, late progression of primary AL amyloidosis to systemic amyloidosis and multiple myeloma is uncommon.

引用

页数：5

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