Radical Nephrectomy After Immune Checkpoint Inhibitors for Metastatic Renal Cell Carcinoma

被引：8

作者：

Yanagisawa, Takafumi ^{[1
,2
]}

Schmidinger, Manuela ^{[1
,9
]}

Kawada, Tatsushi ^{[1
,3
]}

Bekku, Kensuke ^{[1
,3
]}

Kimura, Takahiro ^{[2
]}

Shariat, Shahrokh F. ^{[1
,4
,5
,6
,7
,8
]}

机构：

[1] Med Univ Vienna, Comprehens Canc Ctr, Dept Urol, Vienna, Austria

[2] Jikei Univ, Dept Urol, Sch Med, Tokyo, Japan

[3] Okayama Univ, Dept Urol, Grad Sch Med Dent & Pharmaceut Sci, Okayama, Japan

[4] Univ Jordan, Dept Special Surg, Div Urol, Amman, Jordan

[5] Univ Texas Southwestern Med Ctr, Dept Urol, Dallas, TX USA

[6] Charles Univ Prague, Fac Med 2, Dept Urol, Prague, Czech Republic

[7] Weill Cornell Med Coll, Dept Urol, New York, NY USA

[8] Karl Landsteiner Inst Urol & Androl, Vienna, Austria

[9] Med Univ Vienna, Comprehens Canc Ctr, Dept Urol, Wahringer Gurtel 18-20, A-1090 Vienna, Austria

来源：

EUROPEAN UROLOGY FOCUS | 2023年 / 9卷 / 02期

关键词：

Immune checkpoint inhibitors; Metastatic renal cell carcinoma; Cytoreductive nephrectomy; COMBINATION;

D O I：

10.1016/j.euf.2023.01.022

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Immune checkpoint inhibitors (ICIs) have led to substantial changes in systemic treatment for metastatic renal cell carcinoma (mRCC). For patients whose metastases respond to upfront ICI therapy, deferred cytoreductive nephrectomy (CN) may confer a survival advantage. Further data from ongoing trials are awaited regarding the role of deferred versus immediate CN for mRCC in the ICI era. Patient summary: The first-line treatment currently recommended for kidney cancer that has spread to other sites is immunotherapy. For patients who experience a good response to this treatment, surgical kidney removal to control the primary tumor may have a survival benefit. More evidence from clinical trials is needed to confirm the efficacy of this approach. (c) 2023 The Authors. Published by Elsevier B.V. on behalf of European Association of Urology. This is an open access article under the CC BY license (http://creativecommons. org/licenses/by/4.0/).

引用

页码：275 / 277

页数：3

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