Chemo-free maintenance therapy in adult T-cell acute lymphoblastic leukemia: A case report and literature review

被引：2

作者：

Song, Yuanbin ^{[1
]}

Chen, Shuzhao ^{[1
]}

Liu, Chenfei ^{[1
]}

Chen, Lezong ^{[1
]}

Wang, Weida ^{[1
]}

Wu, Bingyi ^{[1
]}

Liang, Yang ^{[1
]}

机构：

[1] Sun Yat sen Univ, Collaborat Innovat Ctr Canc Med, Dept Hematol Oncol, State Key Lab Oncol South China,Canc Ctr, Guangzhou, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2023年 / 14卷

基金：

中国国家自然科学基金;

关键词：

chemo-free maintenance therapy; anti-programmed cell death protein 1; histone deacetylase inhibitor; T-cell acute lymphoblastic leukemia; case report; literature review; LYMPHOMA; CHEMOTHERAPY; DECITABINE; EXPRESSION; COMBINATION; VORINOSTAT; PROGNOSIS; APOPTOSIS; LBH589; GENES;

D O I：

10.3389/fphar.2023.1051305

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Maintenance therapy in adult T-cell acute lymphoblastic leukemia (T-ALL) is the longest phase but with limited option. The classic drugs used in the maintenance phase such as 6-mercaptopurine, methotrexate, corticosteroid and vincristine have potentially serious toxicities. Optimizing therapy in the modern age, chemo-free maintenance therapy regimens for patients with T-ALL may dramatically improve the maintenance therapeutic landscape. We report here the combination of Anti-programmed cell death protein 1 antibody and histone deacetylase inhibitor as chemo-free maintenance treatment in a T-ALL patient with literature review, thus providing a unique perspective in addition to valuable information which may inform novel therapeutic approaches.

引用

页数：6

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