Synthesis and evaluation of biological activity of some novel carbazole derivatives

被引：1

作者：

Kumar, Umesh ^{[1
]}

Gupta, Sujeet Kumar ^{[1
]}

Yogi, Bhumika ^{[1
]}

Kumar, Surendra ^{[1
]}

机构：

[1] Hygia Inst Pharmaceut Educ & Res, Dept pharmaceut Chem, Lucknow 226020, Uttar Pradesh, India

来源：

INDIAN JOURNAL OF CHEMISTRY | 2023年 / 62卷 / 01期

关键词：

Carbazole; Heterocyclic chemistry; Anti-inflammatory activity; Carrageenan induced Inflammation; Rat paw; Edema model; Diclofenac sodium; AGENTS;

D O I：

10.56042/ijc.v62i1.70394

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Natural and synthetic carbazoles contains potent activity against inflammation. Some novel carbazole derivatives have been synthesized and also checked for activity against inflammation by using Carrageenan Induced Inflammation in Rat Paw Edema Model. Structures of synthesized carbazole derivatives have been confirmed on the basis of FT-IR, 1H NMR and elemental analysis. During the evaluation of biological activity, newly synthesized compounds (4a) and (4f) are found more potent against inflammation.

引用

页码：60 / 64

页数：5

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