Magnetic field effects on radical pair reactions: estimation of B1/2 for flavin-tryptophan radical pairs in cryptochromes

被引:5
|
作者
Wong, Siu Ying [1 ]
Benjamin, Philip [2 ]
Hore, P. J. [2 ]
机构
[1] Carl von Ossietzky Univ Oldenburg, Inst Phys, D-26111 Oldenburg, Germany
[2] Univ Oxford, Dept Chem, Oxford OX1, Oxfordshire, England
基金
欧洲研究理事会;
关键词
ELECTRON-TRANSFER; SPIN-EXCHANGE; RECOMBINATION; MODEL; MAGNETORECEPTION; PHOTOCYCLE; KINETICS;
D O I
10.1039/d2cp03793a
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Magnetic field effects on the yields of radical pair reactions are often characterised by the "half-field" parameter, B-1/2, which encodes useful information on spin relaxation, radical recombination kinetics and electron-electron couplings as well as electron-nuclear hyperfine interactions. Here we use a variety of spin dynamics simulation methods to estimate the hyperfine-only values of B-1/2 for the flavin-tryptophan radical pair, [FAD(-) TrpH(+)], thought to be the detector in the magnetic compass sense of migratory songbirds. The main findings are: (a) in the absence of fast recombination and spin relaxation, [FAD(-) TrpH(+)] radical pairs in solution and in the putative magnetoreceptor protein, cryptochrome, have B-1/2 approximate to 1.89 mT and 2.46 mT, respectively. (b) The widely used expression for B-1/2 due to Weller et al. (Chem. Phys. Lett, 1983, 96, 24-27) is only applicable to small, short-lived (similar to 5 ns), rapidly tumbling radical pairs in solution, and is quantitatively unreliable in the context of magnetoreception. (c) In the absence of molecular tumbling, the low-field effect for [FAD(-) TrpH(+)] is predicted to be abolished by the anisotropic components of the hyperfine interactions. Armed with the 2.46 mT "base value" for cryptochrome, measurements of B-1/2 can be used to understand the impact of spin relaxation on its performance as a magnetic compass sensor.
引用
收藏
页码:975 / 982
页数:8
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