White matter hyperintensities in former American football players

被引：16

作者：

Alosco, Michael L. ^{[1
]}

Tripodis, Yorghos ^{[2
,3
]}

Baucom, Zachary H. ^{[3
]}

Adler, Charles H. ^{[4
]}

Balcer, Laura J. ^{[5
]}

Bernick, Charles ^{[6
,7
]}

Mariani, Megan L. ^{[2
]}

Au, Rhoda ^{[1
,8
,9
,10
,11
]}

Banks, Sarah J. ^{[12
,13
]}

Barr, William B. ^{[14
]}

Wethe, Jennifer, V ^{[15
]}

Cantu, Robert C. ^{[1
]}

Coleman, Michael J. ^{[16
]}

Dodick, David W. ^{[4
]}

McClean, Michael D. ^{[17
]}

McKee, Ann C. ^{[1
,18
]}

Mez, Jesse ^{[1
,8
]}

Palmisano, Joseph N. ^{[19
]}

Martin, Brett ^{[19
]}

Hartlage, Kaitlin ^{[19
]}

Lin, Alexander P. ^{[16
,20
]}

Koerte, Inga K. ^{[16
,21
]}

Cummings, Jeffrey L. ^{[22
]}

Reiman, Eric M. ^{[23
,24
]}

Stern, Robert A. ^{[1
,10
,25
]}

Shenton, Martha E. ^{[16
,26
]}

Bouix, Sylvain ^{[16
,27
]}

机构：

[1] Boston Univ, Sch Med, Alzheimers Dis Res Ctr, CTE Ctr,Dept Neurol, Boston, MA 02118 USA

[2] Boston Univ, Sch Med, CTE Ctr, Alzheimers Dis Res Ctr, Boston, MA 02118 USA

[3] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA

[4] Mayo Clin, Coll Med, Mayo Clin Arizona, Dept Neurol, Scottsdale, AZ USA

[5] NYU Grossman Sch Med, Dept Neurol Populat Hlth & Ophthalmol, New York, NY USA

[6] Cleveland Clin, Lou Ruvo Ctr Brain Hlth, Las Vegas, NV USA

[7] Univ Washington, Dept Neurol, Seattle, WA 98195 USA

[8] Framingham Heart Dis Epidemiol Study, Framingham, MA USA

[9] Boston Univ, Slone Epidemiol Ctr, Boston, MA 02118 USA

[10] Boston Univ, Sch Med, Dept Anat & Neurobiol, Boston, MA 02118 USA

[11] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02118 USA

[12] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA

[13] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA

[14] NYU Grossman Sch Med, Dept Neurol, New York, NY USA

[15] Mayo Clin, Sch Med, Mayo Clin Arizona, Dept Psychiat & Psychol, Scottsdale, AZ USA

[16] Brigham & Womens Hosp, Dept Psychiat, Psychiat Neuroimaging Lab, 75 Francis St, Boston, MA 02115 USA

[17] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02118 USA

[18] VA Boston Healthcare Syst, Boston, MA USA

[19] Boston Univ, Sch Publ Hlth, BEDAC, Boston, MA 02118 USA

[20] Harvard Med Sch, Brigham & Womens Hosp, Ctr Clin Spect, Dept Radiol, Boston, MA 02115 USA

[21] Ludwigs Maximilians Univ, cBRAIN, Dept Child & Adolescent Psychiat Psychosomat & Ps, Munich, Germany

[22] Univ Nevada, Sch Integrated Hlth Sci, Chambers Grundy Ctr Transformat Neurosci, Dept Brain Hlth, Las Vegas, NV 89154 USA

[23] Arizona State Univ, Univ Arizona, Banner Alzheimers Inst, Translat Genom Res Inst, Phoenix, AZ USA

[24] Arizona Alzheimers Consortium, Phoenix, AZ USA

[25] Boston Univ, Sch Med, Dept Neurosurg, Boston, MA 02118 USA

[26] Harvard Med Sch, Brigham & Womens Hosp, Dept Radiol, Boston, MA 02115 USA

[27] Ecole Technol Super, Dept Software Engn & Informat Technol, Montreal, PQ, Canada

来源：

ALZHEIMERS & DEMENTIA | 2023年 / 19卷 / 04期

基金：

美国国家卫生研究院;

关键词：

aging; cerebrovascular disease; concussion; fluid-attenuated inversion recovery; football; microvascular disease; neurodegenerative disease; repetitive head impacts; subconcussion; white matter hyperintensities; white matter injury; TRAUMATIC BRAIN-INJURY; SMALLER THALAMIC VOLUMES; SURFACE-BASED ANALYSIS; SMALL VESSEL DISEASE; ALZHEIMERS-DISEASE; 1ST EXPOSURE; AFRICAN-AMERICANS; ESTIMATED AGE; DEMENTIA; LESIONS;

D O I：

10.1002/alz.12779

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction The presentation, risk factors, and etiologies of white matter hyperintensities (WMH) in people exposed to repetitive head impacts are unknown. We examined the burden and distribution of WMH, and their association with years of play, age of first exposure, and clinical function in former American football players. Methods A total of 149 former football players and 53 asymptomatic unexposed participants (all men, 45-74 years) completed fluid-attenuated inversion recovery magnetic resonance imaging, neuropsychological testing, and self-report neuropsychiatric measures. Lesion Segmentation Toolbox estimated WMH. Analyses were performed in the total sample and stratified by age 60. Results In older but not younger participants, former football players had greater total, frontal, temporal, and parietal log-WMH compared to asymptomatic unexposed men. In older but not younger former football players, greater log-WMH was associated with younger age of first exposure to football and worse executive function. Discussion In older former football players, WMH may have unique presentations, risk factors, and etiologies. Highlights Older but not younger former football players had greater total, frontal, temporal, and parietal lobe white matter hyperintensities (WMH) compared to same-age asymptomatic unexposed men. Younger age of first exposure to football was associated with greater WMH in older but not younger former American football players. In former football players, greater WMH was associated with worse executive function and verbal memory.

引用

页码：1260 / 1273

页数：14

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