Left atrial volume index as a predictor for left atrial appendage thrombus in patients with non-valvular atrial fibrillation receiving appropriate oral anticoagulation therapy: A prospective multi-center study

被引：1

作者：

Shiraki, Hiroaki ^{[1
]}

Tsunamoto, Hiroshi ^{[1
,2
]}

Onishi, Tetsuari ^{[2
]}

Mukai, Jun ^{[3
]}

Shimoura, Hiroyuki ^{[3
]}

Matsuzoe, Hiroki ^{[4
]}

Soga, Fumitaka ^{[5
]}

Imanishi, Junichi ^{[6
]}

Yokota, Shun ^{[7
]}

Sano, Hiroyuki ^{[8
]}

Tanaka, Yusuke ^{[8
]}

Hirata, Ken-ichi ^{[1
]}

Tanaka, Hidekazu ^{[1
,9
]}

机构：

[1] Kobe Univ, Grad Sch Med, Dept Internal Med, Div Cardiovasc Med, Kobe, Japan

[2] Hyogo Prefectural Harima Himeji Gen Med Ctr, Dept Cardiol, Himeji, Hyogo, Japan

[3] Kakogawa Cent City Hosp, Dept Cardiol, Kakogawa, Hyogo, Japan

[4] Yodogawa Christians Hosp, Dept Cardiovasc Med, Osaka, Japan

[5] Osaka Saiseikai Nakatsu Hosp, Div Cardiol, Osaka, Japan

[6] Hyogo Prefectural Awaji Med Ctr, Dept Cardiol, Sumoto, Japan

[7] Kobe Red Cross Hosp, Div Cardiol, Kobe, Japan

[8] Aijinkai Takatsuki Hosp, Div Cardiol, Takatsuki, Japan

[9] Kobe Univ, Grad Sch Med, Dept Internal Med, Div Cardiovasc Med, 7-5-2 Kusunoki Cho,Chuo Ku, Kobe 6500017, Japan

来源：

ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES | 2024年 / 41卷 / 01期

关键词：

anticoagulants; left atrial appendage; left atrium; non-valvular atrial fibrillation; thrombus; transesophageal echocardiography; EUROPEAN ASSOCIATION; AMERICAN SOCIETY; ECHOCARDIOGRAPHY; GUIDELINES; MANAGEMENT; ADULTS; RISK;

D O I：

10.1111/echo.15735

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

ObjectivesWe previously reported a higher left atrial volume index (LAVI) was independently associated with left atrial (LA) appendage (LAA) thrombus formation in 737 patients with non-valvular atrial fibrillation (NVAF) receiving appropriate oral anticoagulation therapy. Since our previous study was a retrospective single-center study, we designed and conducted a prospective multi-center study to verify our findings for LAVI as a predictor of LAA thrombus in patients with NVAF receiving appropriate oral anticoagulation therapy.MethodsThis prospective multi-center study comprised 746 consecutive patients with NVAF recruited between December 2021 and March 2023 from eight institutions in Japan, who were receiving appropriate oral anticoagulation therapy, had undergone transthoracic echocardiography and transesophageal echocardiography (TEE).ResultsLAA thrombi were observed in 21 patients (2.8%). The prevalence of LAA thrombus formation in patients with paroxysmal AF (PAF) was significantly lower than that in patients with non-PAF (0.7% vs. 4.1%, p = .006). LAA thrombus formation was detected in none (0/171) of the patients with normal size LA (LAVI <= 34 mL/m2). The prevalence of LAA thrombus formation in patients with mildly dilated LA (LAVI: 34-49.9 mL/m2) was 2.1% (6/283), but that in PAF patients was low at 1.0% (1/104). Furthermore, this prevalence in patients with severely dilated LA (LAVI >= 50 mL/m2) was high at 5.1% (15/292).ConclusionsThe findings of this prospective multi-center study are consistent with those of our previous study. Thus, the need for TEE prior to catheter ablation or electrical cardioversion can be determined by the level of LAVI.

引用

页数：7

共 16 条

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