Salvage Therapy Including Foscarnet and Ibalizumab for Multidrug Resistant HIV-2 Infection

被引：1

作者：

Bachelard, Antoine ^{[1
,9
]}

Le Hingrat, Quentin ^{[2
,3
]}

Ferre, Valentine-Marie ^{[2
,3
]}

Le, Minh ^{[4
]}

Peytavin, Gilles ^{[3
,4
]}

Damond, Florence ^{[3
]}

Charpentier, Charlotte ^{[3
]}

Goudot, Guillemette Fremont ^{[5
]}

de Bouille, Jeanne Goupil ^{[6
]}

Lariven, Sylvie ^{[1
]}

Delobel, Pierre ^{[7
,8
]}

Yazdanpanah, Yazdan ^{[1
,3
]}

Descamps, Diane ^{[2
,3
]}

Matheron, Sophie ^{[3
]}

Ghosn, Jade ^{[1
,3
,9
]}

机构：

[1] Hop Univ Paris Nord Val Seine, Assistance Publ Hop Paris Nord, Serv Malad Infect & Trop, Site Bichat Claude Bernard, Paris, France

[2] Hop Univ Paris Nord Val Seine, Assistance Publ Hop Paris Nord, Serv Virol, Site Bichat Claude Bernard, Paris, France

[3] Univ Paris Cite, IAME, INSERM UMRS1137, Paris, France

[4] Hop Univ Paris Nord Val Seine, Assistance Publ Hop Paris Nord, Serv Pharmacol, Site Bichat Claude Bernard, Paris, France

[5] CHI Andre Gregoire, Serv Malad Infect, Montreuil, France

[6] Hop Univ Paris Seine St Denis, Assistance Publ Hop Paris, Serv Malad Infect & Trop, Site Avicennes, Bobigny, France

[7] Ctr Hosp Univ Toulouse, Serv Malad Infect & Trop, Toulouse, France

[8] Univ Toulouse III, INSERM UMR1291 CNRS UMR5051, Toulouse, France

[9] Hop Xavier Bichat, Dept Infect Dis, 46 Rue Henri Huchard, F-75018 Paris, France

来源：

CLINICAL INFECTIOUS DISEASES | 2024年 / 78卷 / 04期

关键词：

HIV-2; salvage therapy; ibalizumab; multi-drug resistance; foscarnet; MONOCLONAL-ANTIBODY; GROUP-A;

D O I：

10.1093/cid/ciad695

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We evaluated Ibalizumab (IBA)-containing standardized optimized salvage regimen (with or without a 4-week foscarnet induction) in individuals harboring multidrug-resistant human immunodeficiency virus type 2 (HIV-2). Nine were included; 2 achieved virological suppression after foscarnet induction with a sustained suppression at Week 24 after IBA initiation, and an additional individual at Week 24 after Ibalizumab initiation.

引用

页码：1005 / 1010

页数：6

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