Pathophysiological roles and applications of glycosphingolipids in the diagnosis and treatment of cancer diseases

被引：9
作者：
Jin, Xuefeng [1 ,2 ,3 ]
Yang, Guang-Yu [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, State Key Lab Microbial Metab, Joint Int Res Lab Metab & Dev Sci, Shanghai 200240, Peoples R China
[2] Guangxi Acad Med Sci, Dept Clin Pharmaceut, Nanning 530021, Peoples R China
[3] Peoples Hosp Guangxi Zhuang Autonomous Reg, Nanning 530021, Peoples R China
来源：
PROGRESS IN LIPID RESEARCH | 2023年 / 91卷
基金：
中国国家自然科学基金;
关键词：
Glycosphingolipids; Biological functions; Cancer disease; Targeted therapy; Diagnostic markers; SIALYL-LEWIS-X; RENAL-CELL CARCINOMA; HUMAN BREAST-CANCER; PREOPERATIVE SERUM LEVELS; GANGLIOSIDE GD3 SYNTHASE; HIGH-RISK NEUROBLASTOMA; GROWTH-FACTOR RECEPTOR; KILLER T-CELLS; LUNG-CANCER; ALPHA-GALACTOSYLCERAMIDE;
D O I：
10.1016/j.plipres.2023.101241
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Glycosphingolipids (GSLs) are major amphiphilic glycolipids present on the surface of living cell membranes. They have important biological functions, including maintaining plasma membrane stability, regulating signal transduction, and mediating cell recognition and adhesion. Specific GSLs and related enzymes are abnormally expressed in many cancer diseases and affect the malignant characteristics of tumors. The regulatory roles of GSLs in signaling pathways suggest that they are involved in tumor pathogenesis. GSLs have therefore been widely studied as diagnostic markers of cancer diseases and important targets of immunotherapy. This review describes the tumor-related biological functions of GSLs and systematically introduces recent progress in using diverse GSLs and related enzymes to diagnose and treat tumor diseases. Development of drugs and biomarkers for personalized cancer therapy based on GSL structure is also discussed. These advances, combined with recent progress in the preparation of GSLs derivatives through synthetic biology technologies, suggest a strong future for the use of customized GSL libraries in treating human diseases.
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页数：25
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