Evaluating the Efficiency of Chitosan-Graphene Oxide Hybrid Hydrogels as Drug Delivery Systems

被引：2

作者：

Di Luca, Mariagrazia ^{[1
]}

Poursani, Ensieh ^{[2
]}

Curcio, Manuela ^{[3
]}

Cirillo, Giuseppe ^{[3
]}

Salerno, Antonietta ^{[2
]}

Bolognini, Sara ^{[1
]}

De Filpo, Giovanni ^{[4
]}

Filippi, Sara ^{[5
]}

Vittorio, Orazio ^{[6
]}

Iemma, Francesca ^{[3
]}

Nicoletta, Fiore Pasquale ^{[3
]}

机构：

[1] Univ Pisa, Dept Biol, I-56100 Pisa, Italy

[2] Univ New South Wales, Childrens Canc Inst, Lowy Canc Res Ctr, Randwick, NSW 2052, Australia

[3] Univ Calabria, Dept Pharm Hlth & Nutr Sci, I-87036 Arcavacata Di Rende, Italy

[4] Univ Calabria, Dept Chem & Chem Technol, I-87036 Arcavacata Di Rende, Italy

[5] Univ Pisa, Dept Civil & Ind Engn, I-56122 Pisa, Italy

[6] Univ New South Wales, Sch Biomed Sci, Randwick, NSW 2052, Australia

来源：

MACROMOLECULAR MATERIALS AND ENGINEERING | 2023年 / 308卷 / 11期

关键词：

antimicrobial; chitosan; electro-responsive release; graphene oxide; hybrid hydrogels; ADSORPTION-ISOTHERMS; TRIPOLYPHOSPHATE; ANTIBIOTICS; MECHANISMS; RELEASE;

D O I：

10.1002/mame.202300166

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

With the objective of creating an electro-responsive and antimicrobial device suitable as delivery system for Rose Bengal (RB) to the skin, a hybrid hydrogel combining Chitosan (CS) and Graphene Oxide (GO) are designed, serving as functional polymer support and active filling element, respectively. The hybrid system, synthesized using tripolyphosphate as a crosslinker via ionic gelation, shows a uniform and homogeneous surface, as verified by SEM investigations, high biocompatibility when tested on human fibroblast lung cells MRC-5 cells, and biodegradability in phosphate buffered medium at physiological pH. Drug loading and release experiments, extensively analyzed using suitable mathematical modeling, shows the enhancement of the binding efficiency conferred by GO (534 and 979 mg g(-1) for blank and hybrid hydrogels, respectively) and an electro-responsive behavior (maximum BR release of 36 and 23% at 0 and 12 V, respectively). Additionally, hybrid hydrogel is found to prevent the adhesion of methicillin-resistant Staphylococcus aureus and to kill the bacterial cells by taking advantage of the sustained release of the antimicrobial RB.

引用

页数：11

共 86 条

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