Synthesis of heterocyclic compounds from camphor

被引:0
作者
Alwan, Ensaf S. [1 ]
Bayoumy, Marwa S. [2 ]
Mohareb, Rafat M. [2 ]
机构
[1] Future Univ Egypt, Fac Pharmaceut Sci & Pharmaceut Ind, Dept Pharmaceut Chem, Cairo, Egypt
[2] Cairo Univ, Fac Sci, Dept Chem, Egypt, Giza, Egypt
关键词
Camphor; pyrazole; camphor dimethyl DL-tartrate; thiazole; METAL-COMPLEXES; AMINO-ACIDS; LIGANDS; DERIVATIVES; TRANSFORMATIONS; NITRIMINES; HYDRAZONE; THIAZOLE; PYRAZOLE; OXIME;
D O I
10.25135/acg.oc.150.2303.2741
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
In this review, we demonstrated the synthesis of isatin derivative 3 according to the Mannich reaction. Moreover, the synthesis of substituted enamines 6a-b using urea catalysts were studied. Additionally, the synthesis of azepanes, piperidines, pyrrolidines, pyrazole, pyridine and pyrimidine derivatives were reported. Furthermore, the synthesis of triazolium salts (34), enamines derivatives 39 and 40, tetrapyrazinoporphyrazine magnesium complex (43), ligands 49 and 50, optically active alpha-amino acids 62a, lactam derivative 67, and its isomer alpha-camphidone (68), camphor dimethyl DL-tartrate (Ct diester) (70), and thiazole derivatives from camphor monoterpenes were realized. The biological activities of many compounds were studied toward human cancer cell lines, influenza virus, Streptococcus pneumoniae, Klebsiella pneumoniae, Staphylococcus aureus, Pseudomonas aeruginosa, Methicillin-Resistant Staphylococcus aureus (MRSA), Escherichia coli, Bacillus cereus, Bacillus subtilis and vaccinia virus, showing interesting results.
引用
收藏
页码:54 / 74
页数:21
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