Synergetic effects of polyethylene microplastic and abamectin pesticides on the eyes of zebrafish larvae and adults through activation of apoptosis signaling pathways

被引：12

作者：

Guru, Ajay ^{[1
]}

Rady, Ahmed ^{[2
]}

Darwish, Noura M. ^{[3
]}

Malafaia, Guilherme ^{[4
,5
,6
,7
,8
,11
]}

Arokiyaraj, Selvaraj ^{[9
]}

Arockiaraj, Jesu ^{[10
]}

机构：

[1] SIMATS, Saveetha Dent Coll & Hosp, Dept Pharmacol, Chennai 600077, Tamil Nadu, India

[2] King Saud Univ, Coll Sci, Dept Zool, POB 2455, Riyadh 11451, Saudi Arabia

[3] Ain Shams Univ, Biochem Dept, Fac Sci, POB 11566, Cairo 11566, Egypt

[4] Goiano Fed Inst, Lab Toxicol Appl Environm, Urutai, GO, Brazil

[5] Goiano Fed Inst, Postgrad Program Conservat Cerrado Nat Resources, Urutai, GO, Brazil

[6] Univ Fed Goias, Postgrad Program Biotechnol & Biodivers 16, Goiania, GO, Brazil

[7] Univ Fed Uberlandia, Postgrad Program Ecol Conservat & Biodivers, Uberlandia, MG, Brazil

[8] Brazilian Acad Young Scientists ABJC, Goiania, Brazil

[9] Sejong Univ, Dept Food Sci & Biotechnol, Seoul 05006, South Korea

[10] SRM Inst Sci & Technol, Fac Sci & Humanities, Dept Biotechnol, Toxicol & Pharmacol Lab, Kattankulatur 603203, Tamil Nadu, India

[11] Goiano Fed Inst, Lab Toxicol Appl Environm, Urutai Campus,Rodovia Geraldo Silva Nascimento,2, BR-75790000 Urutai, GO, Brazil

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2023年 / 102卷

关键词：

Polymers; Pesticide; Danio rerio; Freshwater pollution; Biomarkers; OXIDATIVE STRESS; LIPID-PEROXIDATION; EXPOSURE;

D O I：

10.1016/j.etap.2023.104215

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Although the toxicity of microplastics (MPs) and pesticides has recently been described, the possible effects of combining these pollutants are poorly understood. Thus, we evaluated the potential impact of exposure to polyethylene MP (PE-MP) and abamectin (ABM) (alone and combined) in zebrafish. After five days, the combined exposure to MP and ABM decreased the survival rate compared to exposures to individual pollutants. A significant increase in reactive oxygen species (ROS), lipid peroxidation, apoptosis, and impairment in antioxidant response was observed in zebrafish larvae. Morphological changes in the eyes of zebrafish significantly increased in the combined exposure group than in the individual exposure. Furthermore, the bax and p53 expression (specific apoptotic genes) was significantly upregulated after the combined exposure to PE-MP and ABM. So, the synergetic effect of MP and ABM cannot be ignored, and further research on other higher models is required to confirm its consequences.

引用

页数：10

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