Molecular docking analysis of proflavin with the Wnt pathway targets for OSCC

被引：1

作者：

Pazhani, Jayanthi ^{[1
]}

Veeraraghavan, Vishnu Priya ^{[1
]}

Jayaraman, Selvaraj ^{[1
]}

机构：

[1] Saveetha Univ, Dept Biochem, Saveetha Inst Med & Tech Sci, Saveetha Dent Coll & Hosp,Ctr Mol Med & Diagnost C, Chennai 600077, India

来源：

BIOINFORMATION | 2023年 / 19卷 / 04期

关键词：

Oral carcinoma; wnt signaling; proflavine; molecular docking; ORAL-CANCER; CATENIN;

D O I：

10.6026/97320630019464

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Wnt signaling pathway plays a critical role in tumor progression and metastasis of various cancer types. Therefore, it is of interest to document the molecular docking analysis of proflavin with the Wnt pathway targets (GSK3 beta, beta-catenin, and VIM) for oral squamous cell carcinoma (OSCC). These results suggest that targeting the wnt signaling downstream targets with proflavine might leads to the better outcome for therapeutic outcome for the inhibition of invasion and metastasis in oral squamous cell carcinoma.

引用

页码：464 / 466

页数：3

共 13 条

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