Extracellular vesicles as personalized medicine

被引：54

作者：

Beetler, Danielle J. ^{[1
,2
]}

Di Florio, Damian N. ^{[1
,2
]}

Bruno, Katelyn A. ^{[2
,4
,5
]}

Ikezu, Tsuneya ^{[3
]}

March, Keith L. ^{[4
,5
]}

Cooper Jr., Leslie T. ^{[2
]}

Wolfram, Joy ^{[6
,7
]}

Fairweather, DeLisa ^{[1
,2
,8
,9
]}

机构：

[1] Mayo Clin, Ctr Clin & Translat Sci, Rochester, MN 55902 USA

[2] Mayo Clin, Dept Cardiovasc Med, Jacksonville, FL 32224 USA

[3] Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA

[4] Univ Florida, Ctr Regenerat Med, Gainesville, FL 32611 USA

[5] Univ Florida, Div Cardiol, Gainesville, FL 32611 USA

[6] Univ Queensland, Sch Chem Engn, Brisbane, Qld 4072, Australia

[7] Univ Queensland, Australian Inst Bioengn & Nanotechnol, Brisbane, Qld 4072, Australia

[8] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Environm Hlth Sci & Engn, Baltimore, MD 21205 USA

[9] Mayo Clin, 4500 San Pablo Rd, Jacksonville, FL 32224 USA

来源：

MOLECULAR ASPECTS OF MEDICINE | 2023年 / 91卷

基金：

美国国家卫生研究院;

关键词：

Nanomedicine; Regenerative medicine; Cancer; Neurological disease; Viruses; Immune response; GESTATIONAL DIABETES-MELLITUS; INSULINOMA-RELEASED EXOSOMES; CELL-DERIVED MICROPARTICLES; HEPATITIS-C VIRUS; T-CELLS; ENDOTHELIAL MICROPARTICLES; MATERNAL CIRCULATION; MYELOID MICROVESICLES; EPITHELIAL-CELLS; EMERGING ROLE;

D O I：

10.1016/j.mam.2022.101155

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Extracellular vesicles (EVs) are released from all cells in the body, forming an important intercellular commu-nication network that contributes to health and disease. The contents of EVs are cell source-specific, inducing distinct signaling responses in recipient cells. The specificity of EVs and their accumulation in fluid spaces that are accessible for liquid biopsies make them highly attractive as potential biomarkers and therapies for disease. The duality of EVs as favorable (therapeutic) or unfavorable (pathological) messengers is context dependent and remains to be fully determined in homeostasis and various disease states. This review describes the use of EVs as biomarkers, drug delivery vehicles, and regenerative therapeutics, highlighting examples involving viral in-fections, cancer, and neurological diseases. There is growing interest to provide personalized therapy based on individual patient and disease characteristics. Increasing evidence suggests that EV biomarkers and therapeutic approaches are ideal for personalized medicine due to the diversity and multifunctionality of EVs.

引用

页数：14

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